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dc.contributor.authorStubnova, Viera
dc.contributor.authorOs, Ingrid
dc.contributor.authorHøieggen, Aud
dc.contributor.authorSolbu, Marit Dahl
dc.contributor.authorGrundtvig, Morten
dc.contributor.authorWestheim, Arne
dc.contributor.authorAtar, Dan
dc.contributor.authorWaldum-Grevbo, Bård
dc.coverage.spatialNorwaynb_NO
dc.date.accessioned2019-12-20T14:04:27Z
dc.date.available2019-12-20T14:04:27Z
dc.date.created2019-01-16T16:43:13Z
dc.date.issued2019
dc.identifier.citationStubnova, V., et al. (2019). "Gender differences in association between uric acid and all-cause mortality in patients with chronic heart failure." BMC Cardiovasc Disord 19(1): 4.nb_NO
dc.identifier.issn1471-2261
dc.identifier.urihttp://hdl.handle.net/11250/2634336
dc.description.abstractBACKGROUND: Elevated serum uric acid (SUA) is associated with poor prognosis in patients with cardiovascular disease, yet it is still not decided whether the role of SUA is causal or only reflects an underlying disease. The purpose of the study was to investigate if SUA was an independent predictor of 5-year all-cause mortality in a propensity score matched cohort of chronic heart failure (HF) outpatients. Furthermore, to assess whether gender or renal function modified the effect of SUA. METHODS: Patients (n = 4684) from the Norwegian Heart Failure Registry with baseline SUA were included in the study. Individuals in the highest gender-specific SUA quartile were propensity score matched 1:1 with patients in the lowest three SUA quartiles. The propensity score matching procedure created 928 pairs of patients (73.4% males, mean age 71.4 ± 11.5 years) with comparable baseline characteristics. Kaplan Meier and Cox regression analyses were used to investigate the independent effect of SUA on all-cause mortality. RESULTS: SUA in the highest quartile was an independent predictor of all-cause mortality in HF outpatients (hazard ratio (HR) 1.19, 95% confidence interval (CI) 1.03-1.37, p-value 0.021). Gender was found to interact the relationship between SUA and all-cause mortality (p-value for interaction 0.007). High SUA was an independent predictor of all-cause mortality in women (HR 1.65, 95% CI 1.24-2.20, p-value 0.001), but not in men (HR 1.06, 95% CI 0.89-1.25, p-value 0.527). Renal function did not influence the relationship between SUA and all-cause mortality (p-value for interaction 0.539). CONCLUSIONS: High SUA was independently associated with inferior 5-year survival in Norwegian HF outpatients. The finding was modified by gender and high SUA was only an independent predictor of 5-year all-cause mortality in women, not in men.nb_NO
dc.description.sponsorshipThe first author is a research fellow funded by the South-Eastern Norway Regional Health Authority.nb_NO
dc.language.isoengnb_NO
dc.publisherBMCnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectAll-cause mortality; Epidemiology; Gender; Heart failure; Kidney disease; Propensity score; Uric acidnb_NO
dc.titleGender differences in association between uric acid and all-cause mortality in patients with chronic heart failurenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.rights.holder© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.nb_NO
dc.source.pagenumber1-10nb_NO
dc.source.volume19:4nb_NO
dc.source.journalBMC Cardiovascular Disordersnb_NO
dc.source.issue1nb_NO
dc.identifier.doi10.1186/s12872-018-0989-8
dc.identifier.cristin1658655
cristin.unitcode1991,6,0,0
cristin.unitnameDiv Lillehammer
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal