dc.contributor.author | Farup, Per Grønaas | |
dc.contributor.author | Jacobsen, Morten | |
dc.contributor.author | Ligaarden, Solveig Catharina | |
dc.contributor.author | Rudi, Knut | |
dc.coverage.spatial | Norway | nb_NO |
dc.date.accessioned | 2019-12-11T13:05:15Z | |
dc.date.available | 2019-12-11T13:05:15Z | |
dc.date.created | 2012-11-20T11:08:09Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Gastroenterology Research and Practice. 2012, . | nb_NO |
dc.identifier.issn | 1687-6121 | |
dc.identifier.uri | http://hdl.handle.net/11250/2632764 | |
dc.description.abstract | Abstract
INTRODUCTION:
Knowledge of the mechanism of action of probiotics in subjects with irritable bowel syndrome (IBS) is imperfect.
OBJECTIVE:
This trial aimed at discriminating between a direct effect on the gut wall and an indirect effect caused by modulation of the fecal microbiota.
DESIGN:
Randomized, double-blind, crossover trial.
MATERIAL AND METHODS:
Patients with IBS were given one capsule of 10(10) CFU L. plantarum MF 1298 or placebo once daily. Symptoms were registered (score 0-15) and feces collected at the end of each period. The gut microbiota was analyzed with 16S rRNA gene analyses and results reported as proportions of Bacteroides, Faecalibacterium, and Lachnospiraceae and Simpson's D diversity score.
RESULTS:
Sixteen participants (11 women) with a mean age of 50 years (SD 11) were available for the analyses. Intake of L. plantarum MF 1298 was associated with a significant aggravation of symptoms, but neither intake of L. plantarum MF 1298 nor symptoms were associated with the composition of the fecal microbiota (P values >0.10).
CONCLUSIONS:
The trial indicates that the symptomatic aggravation related to intake of L. plantarum MF 1298 was a direct effect of the microbe on the gut wall and not caused by changes in the fecal microbiota. | nb_NO |
dc.description.sponsorship | S. C. Ligaarden and P. G. Farup have received funding from Nofima AS (former Matforsk AS) for the clinical trial. K. Rudi has received funding from the Norwegian University of Science and Technology and Østfold Hospital Trust for the analyses of the gut microbiota. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Hindawi | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Probiotics, Symptoms, and Gut Microbiota: What Are the Relations? A Randomized Controlled Trial in Subjects with Irritable Bowel Syndrome | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.rights.holder | Copyright © 2012 Per G. Farup et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | nb_NO |
dc.source.pagenumber | 6 | nb_NO |
dc.source.journal | Gastroenterology Research and Practice | nb_NO |
dc.identifier.doi | 10.1155/2012/214102 | |
dc.identifier.cristin | 963505 | |
cristin.unitcode | 1991,1,0,0 | |
cristin.unitcode | 1991,3,0,0 | |
cristin.unitname | Stab Helse | |
cristin.unitname | Div Gjøvik | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |