Show simple item record

dc.contributor.authorCórdova-Palomera, Aldo
dc.contributor.authorKaufmann, Tobias
dc.contributor.authorPersson, Karin
dc.contributor.authorAlnæs, Dag
dc.contributor.authorDoan, Nhat Trung
dc.contributor.authorMoberget, Torgeir
dc.contributor.authorLund, Martina Jonette
dc.contributor.authorBarca, Maria Lage
dc.contributor.authorEngvig, Andreas
dc.contributor.authorBrækhus, Anne
dc.contributor.authorEngedal, Knut
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorSelbæk, Geir
dc.contributor.authorWestlye, Lars Tjelta
dc.date.accessioned2017-03-07T12:00:08Z
dc.date.available2017-03-07T12:00:08Z
dc.date.created2017-01-19T08:48:52Z
dc.date.issued2017
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11250/2433130
dc.description.abstractAs findings on the neuropathological and behavioral components of Alzheimer's disease (AD) continue to accrue, converging evidence suggests that macroscale brain functional disruptions may mediate their association. Recent developments on theoretical neuroscience indicate that instantaneous patterns of brain connectivity and metastability may be a key mechanism in neural communication underlying cognitive performance. However, the potential significance of these patterns across the AD spectrum remains virtually unexplored. We assessed the clinical sensitivity of static and dynamic functional brain disruptions across the AD spectrum using resting-state fMRI in a sample consisting of AD patients (n = 80) and subjects with either mild (n = 44) or subjective (n = 26) cognitive impairment (MCI, SCI). Spatial maps constituting the nodes in the functional brain network and their associated time-series were estimated using spatial group independent component analysis and dual regression, and whole-brain oscillatory activity was analyzed both globally (metastability) and locally (static and dynamic connectivity). Instantaneous phase metrics showed functional coupling alterations in AD compared to MCI and SCI, both static (putamen, dorsal and default-mode) and dynamic (temporal, frontal-superior and default-mode), along with decreased global metastability. The results suggest that brains of AD patients display altered oscillatory patterns, in agreement with theoretical premises on cognitive dynamics.en
dc.language.isoeng
dc.titleDisrupted global metastability and static and dynamic brain connectivity across individuals in the Alzheimer's disease continuum
dc.typePeer reviewed
dc.typeJournal article
dc.source.journalScientific Reports
dc.identifier.doi10.1038/srep40268
dc.identifier.cristin1431575
cristin.unitcode1991,0,0,0
cristin.unitnameSykehuset Innlandet HF
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record