• A 36-month follow-up of decline in activities of daily living in individuals receiving domiciliary care 

      Helvik, Anne-Sofie; Høgset, Lisbeth Dyrendal; Bergh, Sverre; Saltyte Benth, Jurate; Kirkevold, Øyvind; Selbæk, Geir (Journal article; Peer reviewed, 2015)
      Background There have been few studies of how personal and instrumental activities of daily living (P-ADL and I-ADL) develop over time in older people receiving domiciliary care. This study aimed at assessing variables ...
    • A 52 month follow-up of functional decline in nursing home residents - Degree of dementia contributes 

      Helvik, Anne-Sofie; Engedal, Knut; Saltyte Benth, Jurate; Selbæk, Geir (Journal article; Peer reviewed, 2014)
      Background: Few have studied how personal activities of daily living (P-ADL) develop over time in nursing home residents with dementia. Thus, the aim was to study variables associated with the development of P-ADL functioning ...
    • Are the Neuroprotective Effects of Exercise Training Systemically Mediated? 

      Tari, Atefe R; Norevik, Cecilie Skarstad; Scrimgeour, Nathan Robert; Kobro-Flatmoen, Asgeir; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; Wrann, Christiane D; Selbæk, Geir; Kivipelt, Miia; Moreira, Jose Bianco Nascimento; Wisloff, Ulrik (Journal article; Peer reviewed, 2019)
      To date there is no cure available for dementia, and the field calls for novel therapeutic targets. A rapidly growing body of literature suggests that regular endurance training and high cardiorespiratory fitness attenuate ...
    • Association between vascular comorbidity and progression of Alzheimer's disease: a two-year observational study in Norwegian memory clinics 

      Eldholm, Rannveig Sakshaug; Persson, Karin Ester Torun; Barca, Maria Lage; Knapskog, Anne Brita; Cavallin, Lena; Engedal, Knut; Selbæk, Geir; Skovlund, Eva; Saltvedt, Ingvild (Peer reviewed; Journal article, 2018)
      Abstract BACKGROUND: Vascular risk factors increase the risk of Alzheimer's disease (AD), but there is limited evidence on whether comorbid vascular conditions and risk factors have an impact on disease progression. The ...
    • Associations of Changes in Cardiorespiratory Fitness and Symptoms of Anxiety and Depression With Brain Volumes: The HUNT Study 

      Zotcheva, Ekaterina; Pintzka, Carl Wolfgang Schøyen; Salvesen, Øyvind; Selbæk, Geir; Håberg, Asta; Ernstsen, Linda (Peer reviewed; Journal article, 2019)
      We investigated the independent and joint associations of changes in estimated cardiorespiratory fitness (eCRF) and symptoms of anxiety and depression with brain volumes in individuals from the general population. Method: ...
    • Being stuck in a vice: The process of coping with severe depression in late life 

      Björklöf, Guro Hanevold; Kirkevold, Marit; Engedal, Knut; Selbæk, Geir; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2015)
      Articles describing older persons’ experiences of coping with severe depression are, to our knowledge, lacking. This article is methodologically grounded in phenomenological hermeneutics, inspired by Paul Ricoeur, and ...
    • Carers’ experiences of timely access to and use of dementia care services in eight European countries 

      Jelley, Hannah; Kerpershoek, Liselot; Verhey, Frans; Wolfs, Claire; de Vugt, Marjolein; Bieber, Anja; Stephan, Astrid; Meyer, Gabriele; Michelet, Mona; Selbæk, Geir; Sjölund, Britt-Marie; Sköldunger, Anders; Hopper, Louise; Irving, Kate; Marques, Maria; Conceição Balsinha, Maria; Gonçalves-Pereira, Manuel; Portolani, Daniel Michael; Zanetti, Orazio; Woods, Bob (Peer reviewed; Journal article, 2019)
      Timely access to care services is crucial to support people with dementia and their family carers to live well. Carers of people with dementia (N = 390), recruited from eight countries, completed semi-structured interviews ...
    • Cortisol levels among older people with and without depression and dementia 

      Barca, Maria Lage; Eldholm, Rannveig Sakshaug; Persson, Karin Ester Torun; Björklöf, Guro Hanevold; Borza, Tom; Telenius, Elisabeth Wiken; Knapskog, Anne-Brita; Brækhus, Anne; Saltvedt, Ingvild; Selbæk, Geir; Engedal, Knut (Peer reviewed; Journal article, 2018)
      ABSTRACTCortisol dysregulation has been reported in dementia and depression. Cortisol levels and its associates were investigated among older people living at home and in nursing homes, in a cross-sectional study. A sample ...
    • Cost analysis of day care centres in Norway 

      Vossius, Corinna Elisabeth; Selbæk, Geir; Saltyte Benth, Jurate; Wimo, A.; Engedal, Knut; Kirkevold, Øyvind; Rokstad, Anne Marie Mork (Journal article; Peer reviewed, 2019)
      Background: Day care services aim to offer meaningful activities and a safe environment for the attendees and a respite for family caregivers while being cost effective. This study compares the use of formal and informal ...
    • The course of neuropsychiatric symptoms in nursing home residents from admission to 30-month follow-up 

      Helvik, Anne-Sofie; Selbæk, Geir; Saltyte Benth, Jurate; Røen, Irene Mari; Bergh, Sverre (Peer reviewed; Journal article, 2018)
      Aim The aim of this study was to describe the prevalence and persistence of clinically significant neuropsychiatric symptoms (NPS) in nursing home residents with dementia, and to study the association between severity ...
    • Distinguishing early and late brain aging from the Alzheimer's disease spectrum: Consistent morphological patterns across independent samples 

      Doan, Nhat Trung; Engvig, Andreas; Zaske, Krystal; Persson, Karin; Lund, Martina Jonette; Kaufmann, Tobias; Còrdova Palomera, Aldo; Alnæs, Dag; Moberget, Torgeir; Brækhus, Anne; Barca, Maria Lage; Nordvik, Jan Egil; Engedal, Knut; Agartz, Ingrid; Selbæk, Geir; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Journal article; Peer reviewed, 2017)
      Abstract Alzheimer's disease (AD) is a debilitating age-related neurodegenerative disorder. Accurate identification of individuals at risk is complicated as AD shares cognitive and brain features with aging. We applied ...
    • Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease 

      Creese, Byron; Vassos, Evangelos; Bergh, Sverre; Athanasiu, Lavinia; Johar, Iskandar; Rongve, Arvid; Medbøen, Ingrid Tøndel; Da Silva, Miguel Vasconcelos; Aakhus, Eivind; Andersen, Fred; Bettella, Francesco; Brækhus, Anne; Djurovic, Srdjan; Paroni, Giulia; Proitsi, Petroula; Saltvedt, Ingvild; Seripa, Davide; Stordal, Eystein; Fladby, Tormod; Aarsland, Dag; Andreassen, Ole Andreas; Ballard, Clive; Selbæk, Geir (Journal article; Peer reviewed, 2019)
      Psychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for ...
    • Factors associated with alcohol consumption and prescribed drugs with addiction potential among older women and men – the Nord-Trøndelag health study (HUNT2 and HUNT3), Norway, a population-based longitudinal study 

      Tevik, Kjerstin Elisabeth; Selbæk, Geir; Engedal, Knut; Seim, Arnfinn; Krokstad, Steinar; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2019)
      BACKGROUND: Little is known about factors associated with alcohol consumption and use of drugs with addiction potential in older adults. The aim of this study was to explore the association between socio-demographic ...
    • Factors associated with consumption of alcohol in older adults - a comparison between two cultures, China and Norway: the CLHLS and the HUNT-study 

      Li, Juan; Wu, Bei; Selbæk, Geir; Krokstad, Steinar; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2017)
      Background There is little knowledge about the consumption of alcohol among Chinese and Norwegian older adults aged 65 years and over. The aim of this study was to investigate the prevalence and factors related to alcohol ...
    • Frailty identified by geriatric assessment is associated with poor functioning, high symptom burden and increased risk of physical decline in older cancer patients: Prospective observational study 

      Kirkhus, Lene; Saltyte Benth, Jurate; Grønberg, Bjørn Henning; Hjermstad, Marianne Jensen; Rostoft, Siri; Harneshaug, Magnus; Selbæk, Geir; Wyller, Torgeir Bruun; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2019)
      Background: Maintaining quality of life including physical functioning is highly prioritized among older cancer patients. Geriatric assessment is a recommended approach to identify patients with increased vulnerability ...
    • Geriatric assessment is superior to oncologists’ clinical judgement in identifying frailty 

      Kirkhus, Lene; Saltyte Benth, Jurate; Kristjansson, Siri Rostoft; Grønberg, Bjørn Henning; Hjermstad, Marianne Jensen; Selbæk, Geir; Wyller, Torgeir Bruun; Harneshaug, Magnus; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2017)
      Background: Frailty is a syndrome associated with increased vulnerability and an important predictor of outcomes in older cancer patients. Systematic assessments to identify frailty are seldom applied, and oncologists’ ...
    • Health-related quality of life in older depressed psychogeriatric patients: one year follow-up 

      Helvik, Anne-Sofie; Corazzini, Kirsten; Selbæk, Geir; Björklöf, Guro Hanevold; Laks, Jerson; Saltyte Benth, Jurate; Østbye, Truls; Engedal, Knut (Peer reviewed; Journal article, 2016)
      Background: Knowledge about long-term change in health related quality of life (HQoL) among older adults after hospitalization for treatment of depression has clinical relevance. The aim was firstly to describe the change ...
    • Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci 

      Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fredrik; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2018)
      A large fraction of genetic risk factors for Alzheimer's Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) ...
    • Mobility and cognition at admission to the nursing home – a cross-sectional study 

      Sverdrup, Karen; Bergh, Sverre; Selbæk, Geir; Røen, Irene Mari; Kirkevold, Øyvind; Tangen, Gro Gujord (Journal article; Peer reviewed, 2018)
      Background Earlier studies show that the main reasons for admission to long-term nursing home care are cognitive impairment and functional impairments of activities of daily life. However, descriptive evidence of mobility ...
    • Modifiable factors affecting older patients' quality of life and physical function during cancer treatment 

      Kirkhus, Lene; Harneshaug, Magnus; Saltyte Benth, Jurate; Grønberg, Bjørn Henning; Rostoft, Siri; Bergh, Sverre; Hjermstad, Marianne Jensen; Selbæk, Geir; Wyller, Torgeir Bruun; Kirkevold, Øyvind; Borza, Tom; Saltvedt, Ingvild; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2019)
      BACKGROUND: Maintaining physical function and quality of life (QoL) are prioritized outcomes among older adults. We aimed to identify potentially modifiable factors affecting older patients' physical function and QoL ...