dc.contributor.author | Rees, Chris A. | |
dc.contributor.author | Colbourn, Tim | |
dc.contributor.author | Hooli, Shubhada | |
dc.contributor.author | King, Carina | |
dc.contributor.author | Lufesi, Norman | |
dc.contributor.author | McCollum, Eric D. | |
dc.contributor.author | Mwansambo, Charles | |
dc.contributor.author | Cutland, Clare | |
dc.contributor.author | Madhi, Shabir Ahmed | |
dc.contributor.author | Nunes, Marta | |
dc.contributor.author | Matthew, Joseph L. | |
dc.contributor.author | Addo-Yobo, Emmanuel | |
dc.contributor.author | Chisaka, Noel | |
dc.contributor.author | Hassan, Mumtaz | |
dc.contributor.author | Hibberd, Patricia L. | |
dc.contributor.author | Jeena, Prakash M. | |
dc.contributor.author | Lozano, Juan M. | |
dc.contributor.author | MacLeod, William B. | |
dc.contributor.author | Patel, Archana | |
dc.contributor.author | Thea, Donald M. | |
dc.contributor.author | Nguyen, Ngoc Tuong Vy | |
dc.contributor.author | Kartasasmita, Cissy B. | |
dc.contributor.author | Lucero, Marilla | |
dc.contributor.author | Awasthi, Shally | |
dc.contributor.author | Bavdekar, Ashish | |
dc.contributor.author | Chou, Monidarin | |
dc.contributor.author | Nymadawa, Pagbajabyn | |
dc.contributor.author | Pape, Jean-William | |
dc.contributor.author | Paranhos-Baccala, Glaucia | |
dc.contributor.author | Picot, Valentina S | |
dc.contributor.author | Rakoto-Andrianarivelo, Mala | |
dc.contributor.author | Rouzier, Vanessa | |
dc.contributor.author | Russomando, Graciela | |
dc.contributor.author | Sylla, Mariam | |
dc.contributor.author | Vanhems, Philippe | |
dc.contributor.author | Wang, Jianwei | |
dc.contributor.author | Asghar, Rai | |
dc.contributor.author | Banajeh, Salem | |
dc.contributor.author | Iqbal, Imran | |
dc.contributor.author | Maulen-Radovan, Irene | |
dc.contributor.author | Mino-Leon, Greta | |
dc.contributor.author | Saha, Samir K | |
dc.contributor.author | Santosham, Mathuram | |
dc.contributor.author | Singhi, Sunit | |
dc.contributor.author | Basnet, Sudha | |
dc.contributor.author | Strand, Tor Arne | |
dc.contributor.author | Bhatnagar, Shinjini | |
dc.contributor.author | Wadhwa, Nitya | |
dc.contributor.author | Lodha, Rakesh | |
dc.contributor.author | Aneja, Satinder | |
dc.contributor.author | Clara, Alexey W. | |
dc.contributor.author | Campbell, Harry | |
dc.contributor.author | Nair, Harish | |
dc.contributor.author | Falconer, Jennifer | |
dc.contributor.author | Qazi, Shamim A | |
dc.contributor.author | Nisar, Yasir B. | |
dc.contributor.author | Neuman, Mark I | |
dc.date.accessioned | 2023-08-11T13:09:16Z | |
dc.date.available | 2023-08-11T13:09:16Z | |
dc.date.created | 2022-06-10T13:25:19Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | BMJ Global Health. 2022, 7 (4), . | en_US |
dc.identifier.issn | 2059-7908 | |
dc.identifier.uri | https://hdl.handle.net/11250/3083635 | |
dc.description.abstract | Introduction: Existing risk assessment tools to identify children at risk of hospitalised pneumonia-related mortality have shown suboptimal discriminatory value during external validation. Our objective was to derive and validate a novel risk assessment tool to identify children aged 2-59 months at risk of hospitalised pneumonia-related mortality across various settings. Methods: We used primary, baseline, patient-level data from 11 studies, including children evaluated for pneumonia in 20 low-income and middle-income countries. Patients with complete data were included in a logistic regression model to assess the association of candidate variables with the outcome hospitalised pneumonia-related mortality. Adjusted log coefficients were calculated for each candidate variable and assigned weighted points to derive the Pneumonia Research Partnership to Assess WHO Recommendations (PREPARE) risk assessment tool. We used bootstrapped selection with 200 repetitions to internally validate the PREPARE risk assessment tool. Results: A total of 27 388 children were included in the analysis (mean age 14.0 months, pneumonia-related case fatality ratio 3.1%). The PREPARE risk assessment tool included patient age, sex, weight-for-age z-score, body temperature, respiratory rate, unconsciousness or decreased level of consciousness, convulsions, cyanosis and hypoxaemia at baseline. The PREPARE risk assessment tool had good discriminatory value when internally validated (area under the curve 0.83, 95% CI 0.81 to 0.84). Conclusions: The PREPARE risk assessment tool had good discriminatory ability for identifying children at risk of hospitalised pneumonia-related mortality in a large, geographically diverse dataset. After external validation, this tool may be implemented in various settings to identify children at risk of hospitalised pneumonia-related mortality. Keywords: Paediatrics; Pneumonia. © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. | en_US |
dc.description.sponsorship | This study was funded by the Bill & Melinda Gates Foundation (#INV 007927) through a grant to the WHO to SQ. The funders had no role in the study
design or in the collection, analysis or interpretation of the data. The funders
did not write the report and had no role in the decision to submit the paper for
publication. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BMJ Publishing Group | en_US |
dc.relation.uri | https://gh.bmj.com/content/bmjgh/7/4/e008143.full.pdf | |
dc.rights | Navngivelse-Ikkekommersiell 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/deed.no | * |
dc.subject | Paediatrics; | en_US |
dc.subject | Pneumonia; | en_US |
dc.title | Derivation and validation of a novel risk assessment tool to identify children aged 2-59 months at risk of hospitalised pneumonia-related mortality in 20 countries | en_US |
dc.title.alternative | Derivation and validation of a novel risk assessment tool to identify children aged 2-59 months at risk of hospitalised pneumonia-related mortality in 20 countries | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. | en_US |
dc.source.pagenumber | 12 | en_US |
dc.source.volume | 7 | en_US |
dc.source.journal | BMJ Global Health | en_US |
dc.source.issue | 4 | en_US |
dc.identifier.doi | 10.1136/bmjgh-2021-008143 | |
dc.identifier.cristin | 2030824 | |
dc.relation.project | [Bill & Melinda Gates Foundation]: [007927] | en_US |
dc.relation.project | [WHO to SQ] | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |