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dc.contributor.authorRees, Chris A.
dc.contributor.authorColbourn, Tim
dc.contributor.authorHooli, Shubhada
dc.contributor.authorKing, Carina
dc.contributor.authorLufesi, Norman
dc.contributor.authorMcCollum, Eric D.
dc.contributor.authorMwansambo, Charles
dc.contributor.authorCutland, Clare
dc.contributor.authorMadhi, Shabir Ahmed
dc.contributor.authorNunes, Marta
dc.contributor.authorMatthew, Joseph L.
dc.contributor.authorAddo-Yobo, Emmanuel
dc.contributor.authorChisaka, Noel
dc.contributor.authorHassan, Mumtaz
dc.contributor.authorHibberd, Patricia L.
dc.contributor.authorJeena, Prakash M.
dc.contributor.authorLozano, Juan M.
dc.contributor.authorMacLeod, William B.
dc.contributor.authorPatel, Archana
dc.contributor.authorThea, Donald M.
dc.contributor.authorNguyen, Ngoc Tuong Vy
dc.contributor.authorKartasasmita, Cissy B.
dc.contributor.authorLucero, Marilla
dc.contributor.authorAwasthi, Shally
dc.contributor.authorBavdekar, Ashish
dc.contributor.authorChou, Monidarin
dc.contributor.authorNymadawa, Pagbajabyn
dc.contributor.authorPape, Jean-William
dc.contributor.authorParanhos-Baccala, Glaucia
dc.contributor.authorPicot, Valentina S
dc.contributor.authorRakoto-Andrianarivelo, Mala
dc.contributor.authorRouzier, Vanessa
dc.contributor.authorRussomando, Graciela
dc.contributor.authorSylla, Mariam
dc.contributor.authorVanhems, Philippe
dc.contributor.authorWang, Jianwei
dc.contributor.authorAsghar, Rai
dc.contributor.authorBanajeh, Salem
dc.contributor.authorIqbal, Imran
dc.contributor.authorMaulen-Radovan, Irene
dc.contributor.authorMino-Leon, Greta
dc.contributor.authorSaha, Samir K
dc.contributor.authorSantosham, Mathuram
dc.contributor.authorSinghi, Sunit
dc.contributor.authorBasnet, Sudha
dc.contributor.authorStrand, Tor Arne
dc.contributor.authorBhatnagar, Shinjini
dc.contributor.authorWadhwa, Nitya
dc.contributor.authorLodha, Rakesh
dc.contributor.authorAneja, Satinder
dc.contributor.authorClara, Alexey W.
dc.contributor.authorCampbell, Harry
dc.contributor.authorNair, Harish
dc.contributor.authorFalconer, Jennifer
dc.contributor.authorQazi, Shamim A
dc.contributor.authorNisar, Yasir B.
dc.contributor.authorNeuman, Mark I
dc.identifier.citationBMJ Global Health. 2022, 7 (4), .en_US
dc.description.abstractIntroduction: Existing risk assessment tools to identify children at risk of hospitalised pneumonia-related mortality have shown suboptimal discriminatory value during external validation. Our objective was to derive and validate a novel risk assessment tool to identify children aged 2-59 months at risk of hospitalised pneumonia-related mortality across various settings. Methods: We used primary, baseline, patient-level data from 11 studies, including children evaluated for pneumonia in 20 low-income and middle-income countries. Patients with complete data were included in a logistic regression model to assess the association of candidate variables with the outcome hospitalised pneumonia-related mortality. Adjusted log coefficients were calculated for each candidate variable and assigned weighted points to derive the Pneumonia Research Partnership to Assess WHO Recommendations (PREPARE) risk assessment tool. We used bootstrapped selection with 200 repetitions to internally validate the PREPARE risk assessment tool. Results: A total of 27 388 children were included in the analysis (mean age 14.0 months, pneumonia-related case fatality ratio 3.1%). The PREPARE risk assessment tool included patient age, sex, weight-for-age z-score, body temperature, respiratory rate, unconsciousness or decreased level of consciousness, convulsions, cyanosis and hypoxaemia at baseline. The PREPARE risk assessment tool had good discriminatory value when internally validated (area under the curve 0.83, 95% CI 0.81 to 0.84). Conclusions: The PREPARE risk assessment tool had good discriminatory ability for identifying children at risk of hospitalised pneumonia-related mortality in a large, geographically diverse dataset. After external validation, this tool may be implemented in various settings to identify children at risk of hospitalised pneumonia-related mortality. Keywords: Paediatrics; Pneumonia. © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.en_US
dc.description.sponsorshipThis study was funded by the Bill & Melinda Gates Foundation (#INV 007927) through a grant to the WHO to SQ. The funders had no role in the study design or in the collection, analysis or interpretation of the data. The funders did not write the report and had no role in the decision to submit the paper for publication.en_US
dc.publisherBMJ Publishing Groupen_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.titleDerivation and validation of a novel risk assessment tool to identify children aged 2-59 months at risk of hospitalised pneumonia-related mortality in 20 countriesen_US
dc.title.alternativeDerivation and validation of a novel risk assessment tool to identify children aged 2-59 months at risk of hospitalised pneumonia-related mortality in 20 countriesen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holderThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:
dc.source.journalBMJ Global Healthen_US
dc.relation.project[Bill & Melinda Gates Foundation]: [007927]en_US
dc.relation.project[WHO to SQ]en_US

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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal