dc.contributor.author | Kvestad, Ingrid | |
dc.contributor.author | Taneja, Sunita | |
dc.contributor.author | Upadhyay, Ravi Prakash | |
dc.contributor.author | Hysing, Mari | |
dc.contributor.author | Bhandari, Nita | |
dc.contributor.author | Strand, Tor A | |
dc.date.accessioned | 2023-08-04T12:36:24Z | |
dc.date.available | 2023-08-04T12:36:24Z | |
dc.date.created | 2020-02-09T09:44:42Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Pediatrics . 2020 Mar;145(3):e20192316. | en_US |
dc.identifier.issn | 0031-4005 | |
dc.identifier.uri | https://hdl.handle.net/11250/3082670 | |
dc.description.abstract | BACKGROUND AND OBJECTIVES: Vitamin B12 and folate are important for normal brain development. Our objective for this study was to measure the effects of 6-month supplementation of vitamin B12 and/or folic acid in early childhood on cognition when the children were 6 to 9 years old. METHODS: The study is a follow-up of a factorial randomized, double-blind, placebo-controlled trial in 1000 North Indian children. Children 6 to 30 months of age were randomly assigned to receive a placebo or 1.8 µg of vitamin B12, 150 mg of folic acid, or both daily for 6 months. After 6 years, we re-enrolled 791 of these children for cognitive assessments. We compared the scores of the main outcomes (the Wechsler Intelligence Scale for Children, Fourth Edition [India], the Crichton Verbal Scale, and subtests of the NEPSY-II) between the study groups. We also measured the associations between markers of the B vitamins (plasma cobalamin, folate, and total homocysteine concentrations) in early childhood and the cognitive outcomes. RESULTS: There were no differences between the intervention groups and the placebo group on the cognitive outcomes. Plasma cobalamin, folate, and total homocysteine concentrations in early childhood were associated with the cognitive outcomes at follow-up in the unadjusted models. These associations disappeared in models adjusted for relevant confounders. CONCLUSIONS: Our findings, from both an observational and a randomized design suggest that vitamin B12 and folate in children 6 to 36 months have limited public health relevance for long-term cognition. | en_US |
dc.description.sponsorship | Thrasher Research Fund (grant 02827) and the Research Council of Norway (grants 172226 and 234495) provided financial support for the original and the follow-up study. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | American Academy of Pediatrics | en_US |
dc.rights | Navngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/deed.no | * |
dc.subject | Vitamin B12; | en_US |
dc.subject | humans; | en_US |
dc.subject | male; | en_US |
dc.subject | language developments; | en_US |
dc.subject | intelligence tests; | en_US |
dc.subject | folic acid; | en_US |
dc.subject | India; | en_US |
dc.subject | Female; | en_US |
dc.subject | double-blind method; | en_US |
dc.subject | cognition; | en_US |
dc.subject | child; | en_US |
dc.subject | Child development; | en_US |
dc.title | Vitamin B12, folate, and cognition in 6-to 9-year-olds: a randomized controlled trial | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | AcceptedVersion | en_US |
dc.source.volume | 145 | en_US |
dc.source.journal | Pediatrics | en_US |
dc.source.issue | 3 | en_US |
dc.identifier.doi | https://doi.org/10.1542/peds.2019-2316 | |
dc.identifier.cristin | 1792298 | |
dc.relation.project | [Research Council of Norway]: [172226] and [234495] | en_US |
dc.relation.project | [Thrasher Research Fund]: [02827] | en_US |
cristin.ispublished | true | |
cristin.fulltext | accepted | |
cristin.qualitycode | 2 | |