dc.contributor.author | Monsen, Anne-Lise Bjørke | |
dc.contributor.author | Varsi, Kristin | |
dc.contributor.author | Sakkestad, Sunniva Todnem | |
dc.contributor.author | Ulvik, Arve | |
dc.contributor.author | Ueland, Per Magne | |
dc.date.accessioned | 2023-05-09T11:14:08Z | |
dc.date.available | 2023-05-09T11:14:08Z | |
dc.date.created | 2022-11-21T10:36:32Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | European Journal of Nutrition. 2022, 1-12. | en_US |
dc.identifier.issn | 1436-6207 | |
dc.identifier.uri | https://hdl.handle.net/11250/3067274 | |
dc.description.abstract | Purpose: Pyridoxal 5´-phosphate (PLP) is the main form of vitamin B6 in humans and functions a coenzyme for more than 160 different enzymatic reactions. The purpose of the study was to find plasma PLP concentrations, which ensure an optimal vitamin B6 status determined by a metabolic marker, in never-pregnant, pregnant and lactating women and their infants.
Methods: In an observational, prospective study, plasma PLP and the metabolic marker, HKr (hydroxykynurenine/(kynurenic acid + anthranilic acid + xanthurenic acid + hydroxyanthranilic acid) were assessed in women (n = 114) from pregnancy week 18 to 6 months postpartum and related to infant status. Never-pregnant women 18-40 years (n = 127) were included as controls.
Results: Compared to controls, plasma PLP decreased during pregnancy and increased postpartum, while HKr increased from week 18 to 6 weeks postpartum, indicating maternal vitamin B6 insufficiency during this period. In never-pregnant women, HKr increased gradually with plasma PLP < 100 nmol/L, and in pregnancy week 28 a sharp increase in HKr was seen at plasma PLP < 30 nmol/L. Despite correcting for maternal vitamin B6 status, infant median plasma PLP decreased with months of exclusive breastfeeding.
Conclusions: Plasma PLP and kynurenine concentrations differ substantially between never-pregnant, pregnant and postpartum women and infants. A plasma PLP concentration in the range of 50-100 nmol/L seems to ensure an optimal vitamin B6 status for never-pregnant women, whereas a plasma PLP > 30 nmol/L in pregnancy week 28 ensures an adequate vitamin B6 status during pregnancy and lactation. Infant vitamin B6 status at age 6 months is inversely correlated to number of months of exclusive breastfeeding. | en_US |
dc.language.iso | eng | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.subject | Infants; | en_US |
dc.subject | Lactation; | en_US |
dc.subject | Postpartum; | en_US |
dc.subject | Pregnancy; | en_US |
dc.subject | Vitamin B6; | en_US |
dc.subject | Women; | en_US |
dc.title | Assessment of vitamin B6 status in never-pregnant, pregnant and postpartum women and their infants | en_US |
dc.title.alternative | Assessment of vitamin B6 status in never-pregnant, pregnant and postpartum women and their infants | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2022. The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | en_US |
dc.source.pagenumber | 1-12 | en_US |
dc.source.volume | 62 | en_US |
dc.source.journal | European Journal of Nutrition | en_US |
dc.source.issue | 2 | en_US |
dc.identifier.doi | 10.1007/s00394-022-03033-4 | |
dc.identifier.cristin | 2077093 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |