dc.contributor.author | Hewitt, Stephen I. | |
dc.contributor.author | Kristinsson, Jon Adalsteinn | |
dc.contributor.author | Aasheim, Erlend T. | |
dc.contributor.author | Høgestøl, Ingvild Kristine | |
dc.contributor.author | Aaseth, Eirik | |
dc.contributor.author | Jahnsen, Jørgen | |
dc.contributor.author | Eriksen, Erik Fink | |
dc.contributor.author | Mala, Tom | |
dc.date.accessioned | 2023-04-12T14:22:02Z | |
dc.date.available | 2023-04-12T14:22:02Z | |
dc.date.created | 2021-01-14T07:21:47Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Obesity Surgery. 2020, 30 (9), 3426-3434. | en_US |
dc.identifier.issn | 0960-8923 | |
dc.identifier.uri | https://hdl.handle.net/11250/3062735 | |
dc.description.abstract | Purpose: Secondary hyperparathyroidism (SHPT) after obesity surgery may affect bone health. Optimal vitamin D levels have not been established to prevent SHPT postoperatively. We investigated whether SHPT differed across threshold levels of serum 25-hydroxyvitamin D (S-25(OH)D) from 6 months up to 5 years after Roux-en-Y gastric bypass (RYGB).
Materials and methods: We included 554 patients at follow-up 5 years postoperatively. Blood samples were analysed for S-25(OH)D, ionized calcium (iCa) and parathyroid hormone (PTH) during follow-up.
Results: PTH and prevalence of SHPT increased from 6 months to 5 years postoperatively, while S-25(OH)D and iCa decreased (all P < 0.001). PTH and SHPT development are related with S-25(OH)D, and PTH differed between all subgroups of S-25(OH)D. SHPT occurred less frequently across all subgroups of S-25(OH)D ≥ 50 nmol/l during follow-up: odds ratio (OR) 0.44 (95% CI 0.36-0.54) in patients with S-25(OH)D ≥ 50 nmol/l, OR 0.38 (0.30-0.49) with S-25(OH)D ≥ 75 nmol/l and OR 0.19 (0.12-0.31) with S-25(OH) D ≥ 100 nmol/l, all compared with S-25(OH)D < 50 nmol/l. At 5 years, 208/554 patients (38%) had SHPT; SHPT was found in 94/188 patients (50%) with S-25(OH)D < 50 nmol/l, in 69/222 (31%) with S-25(OH)D 50-74 nmol/l, in 40/117 (34%) with S-25(OH)D 75-99 nmol/l and in 5/27 (19%) with S-25(OH)D ≥ 100 nmol/l. An interaction existed between S-25(OH)D and iCa. Bone alkaline phosphatase remained increased with SHPT.
Conclusions: A significant relationship existed between S-25(OH)D and development of PTH and SHPT. The prevalence of SHPT was lower with threshold levels 25(OH)D ≥ 50 nmol/l and ≥ 75 nmol/l over the 5 years, and lowest with S-25(OH)D ≥ 100 nmol/l. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.subject | Bariatric surgery; | en_US |
dc.subject | Bone turnover; | en_US |
dc.subject | Calcium; | en_US |
dc.subject | Morbid obesity; | en_US |
dc.subject | Parathyroid hormone; | en_US |
dc.subject | Vitamin D. | en_US |
dc.title | Relationships Between Vitamin D Status and PTH over 5 Years After Roux-en-Y Gastric Bypass: a Longitudinal Cohort Study | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | en_US |
dc.source.pagenumber | 3426-3434 | en_US |
dc.source.volume | 30 | en_US |
dc.source.journal | Obesity Surgery | en_US |
dc.source.issue | 9 | en_US |
dc.identifier.doi | 10.1007/s11695-020-04582-5 | |
dc.identifier.cristin | 1871023 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |