dc.contributor.author | Blom-Høgestøl, Ingvild Kristine | |
dc.contributor.author | Aasbrenn, Martin | |
dc.contributor.author | Chahal-Kummen, Monica | |
dc.contributor.author | Brunborg, Cathrine | |
dc.contributor.author | Eribe, Inger | |
dc.contributor.author | Kristinsson, Jon Adalsteinn | |
dc.contributor.author | Farup, Per Grønaas | |
dc.contributor.author | Mala, Tom | |
dc.date.accessioned | 2023-04-12T09:26:47Z | |
dc.date.available | 2023-04-12T09:26:47Z | |
dc.date.created | 2020-01-06T21:05:06Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | BMC Gastroenterology. 2019, 19:204 1-11. | en_US |
dc.identifier.issn | 1471-230X | |
dc.identifier.uri | https://hdl.handle.net/11250/3062574 | |
dc.description.abstract | BACKGROUND: Irritable bowel syndrome (IBS) is prevalent in patients with morbid obesity. After Roux-en-Y gastric bypass (RYGB) chronic abdominal pain is common, however the etiology is largely unknown. We aimed to study the change in the prevalence of IBS-like symptoms 2 years after RYGB and possible preoperative predictors of such symptoms. Secondly, to evaluate changes in symptoms of constipation and diarrhea, and Health related quality of life (HRQoL). METHODS: Patients with morbid obesity were included at two obesity centers in South-Eastern Norway. IBS was diagnosed according to the Rome III criteria. Predictors were evaluated in a multivariable logistic regression analysis. RESULTS: Of 307 participants operated with RYGB, 233 (76%) completed the study questionnaires. Preoperatively 27/233 participants (12%) had IBS, 2 years after RYGB 61/233 (26%) had IBS-like symptoms (p < 0.001). Eleven participants with IBS preoperatively (41%) did not report such symptoms after RYGB. New onset IBS-like symptoms was identified in 45/206 (22%) after RYGB. Fibromyalgia, low LDL levels, high vitamin B1 levels and IBS before RYGB were independent preoperative predictors of IBS-like symptoms at the follow-up visit. Symptom scores for constipation preoperatively and 2 year after RYGB were 1.5 (0.9) and 1.8 (1.2), and for diarrhea 1.4 (0.9) and 1.8 (1.1), respectively (p < 0.001). We observed a significant improvement in the physical component score for all participants. However, participants with new onset IBS-like symptoms had a significant worsening of the mental component score. CONCLUSIONS: The prevalence of IBS-like symptoms doubled 2 years after RYGB, and these symptoms were associated with reduced HRQoL. Preoperative IBS and fibromyalgia were strong predictors of postoperative IBS-like symptoms. | en_US |
dc.description.sponsorship | The first author (IKBH) has received a PhD grant from South-Eastern Norway
Regional Health authority, project nr 2014073. The project has received a
financial grant from the Norwegian Gastroenterology Association, but had
no role in the design of the study, data collection, analysis and interpretation
of data or in writing the manuscript. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BioMed Central | en_US |
dc.relation.uri | https://bmcgastroenterol.biomedcentral.com/track/pdf/10.1186/s12876-019-1103-0 | |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.subject | Fibromyalgia; | en_US |
dc.subject | Gastrointestinal symptoms; | en_US |
dc.subject | Health related quality of life; | en_US |
dc.subject | Irritable bowel syndrome; | en_US |
dc.subject | Morbid obesity; | en_US |
dc.subject | Roux-en-Y gastric bypass. | en_US |
dc.title | Irritable bowel syndrome-like symptoms and health related quality of life two years after Roux-en-Y gastric bypass - a prospective cohort study | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © The Author(s). 2019 Open Access
This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | en_US |
dc.source.pagenumber | 1-11 | en_US |
dc.source.volume | 19:204 | en_US |
dc.source.journal | BMC Gastroenterology | en_US |
dc.source.issue | 1 | en_US |
dc.identifier.doi | 10.1186/s12876-019-1103-0 | |
dc.identifier.cristin | 1767238 | |
dc.relation.project | Helse Sør-Øst RHF: 2014073 | en_US |
cristin.unitcode | 1991,3,0,0 | |
cristin.unitcode | 1991,1,2,0 | |
cristin.unitname | Div Gjøvik | |
cristin.unitname | Avd Forskning | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |