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dc.contributor.authorPedersen, Maria
dc.contributor.authorAsprusten, Tarjei Tørre
dc.contributor.authorGodang, Kristin
dc.contributor.authorLeegaard, Truls Michael
dc.contributor.authorOsnes, Liv T. N.
dc.contributor.authorSkovlund, Eva
dc.contributor.authorTjade, Trygve Olav
dc.contributor.authorØie, Merete Glenne
dc.contributor.authorWyller, Vegard Bruun Bratholm
dc.identifier.citationBrain, behavior, and immunity. 2018, 1-7.en_US
dc.description.abstractIntroduction: Acute Epstein-Barr virus (EBV) infection is a trigger of chronic fatigue and Chronic Fatigue Syndrome (CFS). This study investigated baseline predictors of chronic fatigue six months after an acute EBV infection. Materials and methods: A total of 200 adolescents (12-20 years old) with acute EBV infection were assessed for 149 possible baseline predictors and followed prospectively. We performed linear regression to assess possible associations between baseline predictors and fatigue (Chalder Fatigue Questionnaire total score) six months after the acute EBV infection. A total of 70 healthy controls were included for cross-sectional reference. This study is part of the CEBA-project (Chronic fatigue following acute Epstein-Barr virus infection in adolescents). Results: In the final multiple linear regression model, fatigue six months after acute EBV infection was significantly and independently predicted by the following baseline variables (regression coefficient B[95% CI]): Sensory sensitivity (0.8[0.09-1.6]), pain severity (0.2[0.02-0.3]), functional impairment (1000 steps/day) (-0.3[-0.5 to -0.08]), negative emotions (anxiety) (0.4[0.2-0.6]), verbal memory (correct word recognition) (1.7[0.1-3.3]), plasma C-reactive protein (2.8[1.1-4.4] for CRP values >0.86) and plasma Vitamin B12 (-0.005[-0.01 to -0.001]). Conclusions: Development of fatigue after acute EBV infection is to a larger extent predicted by baseline variables related to symptoms and functions than to baseline variables reflecting infectious and immune processes. Trial registration: ClinicalTrials, ID: NCT02335437,
dc.description.sponsorshipThis study was founded by the Health South–East Hospital Trust, Norway.en_US
dc.publisherElsevier Inc.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.subjectChronic Fatigue Syndrome;en_US
dc.subjectChronic fatigue;en_US
dc.subjectEpstein-Barr virus infection;en_US
dc.subjectInfectious mononucleosisen_US
dc.titlePredictors of chronic fatigue in adolescents six months after acute Epstein-Barr virus infection: a prospective cohort studyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2018 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND licenseen_US
dc.source.journalBrain, behavior, and immunityen_US
cristin.unitnameAvd Forskning

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal