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dc.contributor.authorEriksen, Guro Falk
dc.contributor.authorSaltyte Benth, Jurate
dc.contributor.authorGrønberg, Bjørn Henning
dc.contributor.authorRostoft, Siri
dc.contributor.authorKirkevold, Øyvind
dc.contributor.authorBergh, Sverre
dc.contributor.authorHjelstuen, Anne Kristine
dc.contributor.authorRolfson, Darryl
dc.contributor.authorJordhøy, Marit Slaaen
dc.identifier.citationEriksen, G. F., Šaltytė Benth, J., Grønberg, B. H., Rostoft, S., Kirkevold, Ø., Bergh, S., Hjelstuen, A., et al. (2022). Cognitive Trajectories in Older Patients with Cancer Undergoing Radiotherapy—A Prospective Observational Study. Current Oncology, 29(7), 5164–5178. MDPI AG. Retrieved from
dc.description.abstractCognitive function can be affected by cancer and/or its treatment, and older patients are at a particular risk. In a prospective observational study including patients 65 years referred for radiotherapy (RT), we aimed to investigate the association between patient- and cancer-related factors and cognitive function, as evaluated by the Montreal Cognitive Assessment (MoCA), and sought to identify groups with distinct MoCA trajectories. The MoCA was performed at baseline (T0), RT completion (T1), and 8 (T2) and 16 (T3) weeks later, with scores ranging between 0 and 30 and higher scores indicating better function. Linear regression and growth mixture models were estimated to assess associations and to identify groups with distinct MoCA trajectories, respectively. Among 298 patients with a mean age of 73.6 years (SD 6.3), the baseline mean MoCA score was 24.0 (SD 3.7). Compared to Norwegian norm data, 37.9% had cognitive impairment. Compromised cognition was independently associated with older age, lower education, and physical impairments. Four groups with distinct trajectories were identified: the very poor (6.4%), poor (8.1%), fair (37.9%), and good (47.7%) groups. The MoCA trajectories were mainly stable. We conclude that cognitive impairment was frequent but, for most patients, was not affected by RT. For older patients with cancer, and in particular for those with physical impairments, we recommend an assessment of cognitive function.en_US
dc.description.sponsorshipThis work was funded by Innlandet Hospital Trust, Norway. This research received no external funding.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.subjectMontreal Cognitive Assessment;en_US
dc.subjectcancer-related cognitive impairment;en_US
dc.subjectgeriatric oncology;en_US
dc.subjectcognitive function;en_US
dc.subjectphysical impairment;en_US
dc.titleCognitive Trajectories in Older Patients with Cancer Undergoing Radiotherapy—A Prospective Observational Studyen_US
dc.title.alternativeCognitive Trajectories in Older Patients with Cancer Undergoing Radiotherapy—A Prospective Observational Studyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/).en_US
dc.source.journalCurrent Oncologyen_US

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