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dc.contributor.authorAndersen, Jacqueline Kirsti
dc.contributor.authorOma, Ingvild
dc.contributor.authorPrayson, Richard A.
dc.contributor.authorKveldstad, Ingjerd Lien
dc.contributor.authorAlmdahl, Sven Martin
dc.contributor.authorFagerland, Morten
dc.contributor.authorHollan, Ivana
dc.identifier.citationArthritis Res Ther . 2016 Oct 12;18(1):232.en_US
dc.description.abstractBackground The cause of premature cardiovascular disease (CVD) in inflammatory rheumatic diseases (IRDs) has not been fully elucidated. As inflammation may play a role, we wanted to compare the occurrence and extent of inflammatory cell infiltrates (ICIs), small vessel vasculitis, and the amount of adipose tissue and collagen in cardiac biopsies taken from patients with coronary artery disease with and without IRDs. Methods From among the Feiring Heart Biopsy Study subjects, we selected patients undergoing coronary artery bypass grafting from whom paraffin-embedded, formalin-fixed specimens from the right atrium were available. The sample comprised 48 patients with IRD and 40 non-IRD patients. Hematoxylin and eosin staining was used to examine the presence and location of ICIs and vasculitis, and Lendrum (Martius yellow, scarlet, and blue) staining was carried out for collagen and adipose tissue. Results Epicardial ICIs were found in 27 (56 %) patients with IRD and 24 (60 %) non-IRD patients. There were no significant differences between patients with IRD and non-IRD patients in the amount of cardiac ICIs and adipose tissue, but patients with IRD had more collagen in the myocardium than non-IRD patients. Small vessel vasculitis was not observed in any cardiac specimen. Patients with epicardial ICIs were, on average, 7 years younger than those without. Conclusions Our results do not support the notion that inflammation in cardiac peri-, epi-, and myocardium plays a more important role in CVD of patients with IRD than non-IRD patients. The increased amount of collagen in the myocardium of patients with IRD suggests differences in extracellular matrix composition and/or mass, which might play a role in cardiac remodeling, and represent targets for novel therapies against heart failure.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.subjectCardiovascular disease;en_US
dc.subjectEpicardial adipose tissue;en_US
dc.subjectExtracellular matrix;en_US
dc.subjectInflammatory rheumatic diseases;en_US
dc.subjectRight atriumen_US
dc.titleInflammatory cell infiltrates in the heart of patients with coronary artery disease with and without inflammatory rheumatic disease: A biopsy studyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holderThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.en_US
dc.source.journalArthritis Research & Therapyen_US

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