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dc.contributor.authorBarca, Maria Lage
dc.contributor.authorPersson, Karin
dc.contributor.authorEldholm, Rannveig Sakshaug
dc.contributor.authorSaltyte Benth, Jurate
dc.contributor.authorKersten, Hege
dc.contributor.authorKnapskog, Anne-Brita
dc.contributor.authorSaltvedt, Ingvild
dc.contributor.authorSelbæk, Geir
dc.contributor.authorEngedal, Knut
dc.date.accessioned2020-06-25T07:43:07Z
dc.date.available2020-06-25T07:43:07Z
dc.date.created2017-07-18T10:30:38Z
dc.date.issued2017
dc.identifier.citationJournal of Affective Disorders. 2017, 222 146-152.en_US
dc.identifier.issn0165-0327
dc.identifier.urihttps://hdl.handle.net/11250/2659407
dc.description.abstractBackground The relationship between progression of Alzheimer's disease and depression and its underlying mechanisms has scarcely been studied. Methods A sample of 282 outpatients with Alzheimer's disease (AD; 105 with amnestic AD and 177 with Alzheimer's dementia) from Norway were followed up for an average of two years. Assessment included Cornell Scale for Depression in Dementia and Clinical Dementia Rating Scale (CDR) at baseline and follow-up to examine the relationship between AD and depression. Additionally, MRI of the brain, CSF dementia biomarkers and APOE status were assessed at baseline. Progression of dementia was defined as the difference between CDR sum of boxes at follow-up and baseline (CDR-SB change). Trajectories of depressive symptoms on the Cornell Scale were identified using growth mixture modeling. Differences between the trajectories in regard to patients’ characteristics were investigated. Results Three distinct trajectories of depressive symptoms were identified: 231 (82.8%) of the patients had stable low-average scores on the Cornell Scale (Class 1); 11 (3.9%) had high and decreasing scores (Class 2); and 37 (13.3%) had moderate and increasing scores (Class 3). All classes had average probabilities over 80%, and confidence intervals were non-overlapping. The only significant characteristic associated with membership in class 3 was CDR-SB change. Limitations Not all patients screened for participation were included in the study, but the included and non-included patients did not differ significantly. Some patients with amnestic MCI might have been misdiagnosed. Conclusion A more rapid progression of dementia was found in a group of patients with increasing depressive symptoms.en_US
dc.language.isoengen_US
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S016503271730397X?via%3Dihub
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.subjectDementiaen_US
dc.subjectDepressionen_US
dc.subjectMemory clinicen_US
dc.subjectMild cognitive impairmenten_US
dc.subjectPrognosisen_US
dc.subjectTrajectoryen_US
dc.titleTrajectories of depressive symptoms and their relationship to the progression of dementiaen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionacceptedVersionen_US
dc.rights.holderCopyright © 2017 Elsevier.en_US
dc.source.pagenumber146-152en_US
dc.source.volume222en_US
dc.source.journalJournal of Affective Disordersen_US
dc.identifier.doi10.1016/j.jad.2017.07.008
dc.identifier.cristin1482481
cristin.unitcode1991,9,1,0
cristin.unitnameAvd Alderspsykiatri
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal