dc.contributor.author | Frigstad, Svein Oskar | |
dc.contributor.author | Høivik, Marte Lie | |
dc.contributor.author | Jahnsen, Jørgen | |
dc.contributor.author | Småstuen, Milada Cvancarova | |
dc.contributor.author | Grimstad, Tore | |
dc.contributor.author | Berset, Ingrid Prytz | |
dc.contributor.author | Huppertz-Hauss, Gert | |
dc.contributor.author | Hovde, Øistein | |
dc.contributor.author | Bernklev, Tomm | |
dc.contributor.author | Moum, Bjørn | |
dc.contributor.author | Jelsness-Jørgensen, Lars-Petter | |
dc.date.accessioned | 2020-05-29T13:25:03Z | |
dc.date.available | 2020-05-29T13:25:03Z | |
dc.date.created | 2020-01-02T09:29:55Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Nutrients . 2019 Dec 20;12(1):26. doi: 10.3390/nu12010026. | en_US |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | https://hdl.handle.net/11250/2656057 | |
dc.description.abstract | Pain and vitamin D deficiency are common in inflammatory bowel disease (IBD). Disease activity, fatigue, frequent relapses, prior surgery and psychological factors all seem to influence the experience of pain in IBD. Vitamin D deficiency has been associated with muscle and skeletal pain. This study aimed to determine whether there is an association between vitamin D deficiency and severity of pain in patients with IBD, and to investigate the influence of other socio-demographic and psychological variables on the experience of pain. Methods: Patients with IBD were recruited from nine hospitals in Norway in a multicenter cross-sectional study. The Brief Pain Inventory (BPI) questionnaire was used to measure pain. Disease activity was assessed using clinical disease activity indices, C-reactive protein (CRP) and fecal calprotectin. Regression models were fitted to explore a possible association between 25-hydroxyvitamin D and pain severity. Results: Of 407 patients included in the analyses, 229 (56%) had Crohn's disease (CD) and 178 (44%) had ulcerative colitis (UC). Vitamin D deficiency was present in half (203/407) of patients. Presence of pain was reported by 76% (309/407). More severe pain was associated with female gender and increased disease activity scores, but not with increased CRP or fecal calprotectin. In CD, patients without prior intra-abdominal surgery reported more severe pain. In multivariate analyses, there was no association between 25-hydroxyvitamin D and pain severity. Conclusions: In this study, no significant association between pain severity and vitamin D deficiency was revealed in patients with IBD. | en_US |
dc.description.sponsorship | This work was supported by a research grant from Tillotts Pharma and Østfold Hospital Trust, Norway.
Editorial support was provided by Cambridge Medical Ltd., UK in agreement with Pharmacosmos AS, Denmark.
The sponsors had no role in the design, execution, interpretation, or writing of the study. | en_US |
dc.language.iso | eng | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.subject | vitamin D deficiency; | en_US |
dc.subject | pain severity; | en_US |
dc.subject | patient reported outcomes | en_US |
dc.title | Pain Severity and Vitamin D Deficiency in IBD Patients | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/). | en_US |
dc.source.pagenumber | 1-12 | en_US |
dc.source.volume | 12 | en_US |
dc.source.journal | Nutrients | en_US |
dc.source.issue | 1 | en_US |
dc.identifier.doi | 10.3390/nu12010026 | |
dc.identifier.cristin | 1764879 | |
cristin.unitcode | 1991,3,0,0 | |
cristin.unitname | Div Gjøvik | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |