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dc.contributor.authorHelsingen, Lise M.
dc.contributor.authorVandvik, Per Olav
dc.contributor.authorJodal, Henriette C.
dc.contributor.authorAgoritsas, Thomas
dc.contributor.authorLytvyn, Lyubov
dc.contributor.authorAnderson, Joseph C.
dc.contributor.authorAuer, Reto
dc.contributor.authorMurphy, Silje Bjerkelund
dc.contributor.authorAlmadi, Majid Abdulrahman
dc.contributor.authorCorley, Douglas A.
dc.contributor.authorQuinlan, Casey
dc.contributor.authorFuchs, Jonathan M.
dc.contributor.authorMcKinnon, Annette
dc.contributor.authorQaseem, Amir
dc.contributor.authorHeen, Anja Fog
dc.contributor.authorSiemieniuk, Reed A.C.
dc.contributor.authorKalager, Mette
dc.contributor.authorUsher-Smith, Juliet A.
dc.contributor.authorLansdorp-Vogelaar, Iris
dc.contributor.authorBretthauer, Michael
dc.contributor.authorGuyatt, Gordon
dc.identifier.citationBMJ. 2019 Oct 2;367:l5515. doi: 10.1136/bmj.l5515en_US
dc.description.abstractCLINICAL QUESTION: Recent 15-year updates of sigmoidoscopy screening trials provide new evidence on the effectiveness of colorectal cancer screening. Prompted by the new evidence, we asked: "Does colorectal cancer screening make an important difference to health outcomes in individuals initiating screening at age 50 to 79? And which screening option is best?" CURRENT PRACTICE: Numerous guidelines recommend screening, but vary on recommended test, age and screening frequency. This guideline looks at the evidence and makes recommendations on screening for four screening options: faecal immunochemical test (FIT) every year, FIT every two years, a single sigmoidoscopy, or a single colonoscopy. RECOMMENDATIONS: These recommendations apply to adults aged 50-79 years with no prior screening, no symptoms of colorectal cancer, and a life expectancy of at least 15 years. For individuals with an estimated 15-year colorectal cancer risk below 3%, we suggest no screening (weak recommendation). For individuals with an estimated 15-year risk above 3%, we suggest screening with one of the four screening options: FIT every year, FIT every two years, a single sigmoidoscopy, or a single colonoscopy (weak recommendation). With our guidance we publish the linked research, a graphic of the absolute harms and benefits, a clear description of how we reached our value judgments, and linked decision aids. HOW THIS GUIDELINE WAS CREATED: A guideline panel including patients, clinicians, content experts and methodologists produced these recommendations using GRADE and in adherence with standards for trustworthy guidelines. A linked systematic review of colorectal cancer screening trials and microsimulation modelling were performed to inform the panel of 15-year screening benefits and harms. The panel also reviewed each screening option's practical issues and burdens. Based on their own experience, the panel estimated the magnitude of benefit typical members of the population would value to opt for screening and used the benefit thresholds to inform their recommendations. THE EVIDENCE: Overall there was substantial uncertainty (low certainty evidence) regarding the 15-year benefits, burdens and harms of screening. Best estimates suggested that all four screening options resulted in similar colorectal cancer mortality reductions. FIT every two years may have little or no effect on cancer incidence over 15 years, while FIT every year, sigmoidoscopy, and colonoscopy may reduce cancer incidence, although for FIT the incidence reduction is small compared with sigmoidoscopy and colonoscopy. Screening related serious gastrointestinal and cardiovascular adverse events are rare. The magnitude of the benefits is dependent on the individual risk, while harms and burdens are less strongly associated with cancer risk. UNDERSTANDING THE RECOMMENDATION: Based on benefits, harms, and burdens of screening, the panel inferred that most informed individuals with a 15-year risk of colorectal cancer of 3% or higher are likely to choose screening, and most individuals with a risk of below 3% are likely to decline screening. Given varying values and preferences, optimal care will require shared decision making.en_US
dc.description.sponsorshipFunding: This guideline was not funded.en_US
dc.rightsNavngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal*
dc.subjectinflammatory bowel disease;en_US
dc.subjectColorectal cancer;en_US
dc.subjectfaecal immunochemical testing;en_US
dc.subjectadults aged 50-79 yearsen_US
dc.titleColorectal cancer screening with faecal immunochemical testing, sigmoidoscopy or colonoscopy: A clinical practice guidelineen_US
dc.typePeer revieweden_US
dc.typeJournal articleen
dc.rights.holderPublished by the BMJ Publishing Group Limited.en_US

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Navngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal