dc.contributor.author | Farup, Per Grønaas | |
dc.contributor.author | Lydersen, Stian | |
dc.contributor.author | Valeur, Jørgen | |
dc.date.accessioned | 2020-04-28T12:57:28Z | |
dc.date.available | 2020-04-28T12:57:28Z | |
dc.date.created | 2019-10-01T20:28:34Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Journal of Obesity. 2019, 2019 1-8. | en_US |
dc.identifier.issn | 2090-0708 | |
dc.identifier.uri | https://hdl.handle.net/11250/2652786 | |
dc.description.abstract | Obesity has been associated with changes in the gut microbiota and its metabolites. The study explored changes in the faecal microbiota and short-chain fatty acids (SCFA) associated with the diet (including nonnutritive sweeteners (NNSs)) and evaluated metabolic consequences in subjects with morbid obesity. The diet was assessed with a validated food frequency questionnaire. One unit of NNSs was 100 mL beverage with NNSs or 2 tablets/teaspoons of NNSs. The faecal microbiota was assessed with GA-map® dysbiosis test and SCFA with gas chromatography and flame ionisation detection. Fourteen men and 75 women with a mean age of 44.6 (SD 8.7) years, BMI 41.8 (SD 3.6) kg/m2, and intake of NNSs 7.5 units/day (SD 3.2; range 0-43) were included. Faecal butyric acid was positively and negatively associated with the intake of starch (partial correlation = 0.264; p=0.015) and NNSs (partial correlation = -0.274; p=0.011), respectively. NNSs were associated with changes in four out of 39 bacterial groups. Butyric acid has antiobesogenic effects, reduces insulin resistance, and improves dyslipidaemia. Since the weight-reducing effect of NNSs on obese adults trying to lose weight is dubious, it seems imprudent to use NNSs that might counteract the favourable effects of butyric acid. | en_US |
dc.description.sponsorship | The study was funded by Innlandet Hospital Trust, Brumunddal and Norwegian University of Science and Technology, Trondheim, Norway. | en_US |
dc.language.iso | eng | en_US |
dc.relation.uri | http://downloads.hindawi.com/journals/jobe/2019/4608315.pdf | |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.subject | obesity | en_US |
dc.subject | nonnutritive sweeteners | en_US |
dc.subject | fatty acids | en_US |
dc.subject | Diet | en_US |
dc.subject | Faecal Microbiota | en_US |
dc.subject | Morbidly Obese Subjects | en_US |
dc.title | Are Nonnutritive Sweeteners Obesogenic? Associations between Diet, Faecal Microbiota, and Short-Chain Fatty Acids in Morbidly Obese Subjects | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright © 2019 Per G. Farup et al.
This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.source.pagenumber | 1-8 | en_US |
dc.source.volume | 2019 | en_US |
dc.source.journal | Journal of Obesity | en_US |
dc.identifier.doi | 10.1155/2019/4608315 | |
dc.identifier.cristin | 1732740 | |
cristin.unitcode | 1991,1,2,0 | |
cristin.unitname | Avd Forskning | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |