dc.contributor.author | Rolfsjord, Leif Bjarte | |
dc.contributor.author | Skjerven, Håvard Ove | |
dc.contributor.author | Bakkeheim, Egil | |
dc.contributor.author | Berents, Teresa Løvold | |
dc.contributor.author | Carlsen, Kai-Håkon | |
dc.contributor.author | Carlsen, Karin C. Lødrup | |
dc.coverage.spatial | Norway | en_US |
dc.date.accessioned | 2020-03-12T13:48:58Z | |
dc.date.available | 2020-03-12T13:48:58Z | |
dc.date.created | 2019-11-26T20:00:20Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | PLOS ONE. 2019, 14:e0214040 (8), 1-17. | en_US |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://hdl.handle.net/11250/2646618 | |
dc.description.abstract | Abstract BACKGROUND: Children with atopic disease may have reduced health-related quality of life (QoL) and morning cortisol. Possible links between QoL, morning cortisol and atopic disease are unclear. We aimed to determine if QoL was associated with morning salivary cortisol at two years of age, and if asthma, atopic dermatitis and/or allergic sensitisation influenced this association. Secondarily, we aimed to determine if QoL at one year of age was associated with salivary cortisol one year later. METHODS AND FINDINGS: The Bronchiolitis All SE-Norway study included infants during hospitalisation for acute bronchiolitis in infancy (bronchiolitis group) and population-based control infants (controls). The present study included all 358 subjects with available Infant Toddler Quality of Life Questionnaire (ITQOL) from parents, consisting of 13 domains and morning salivary cortisol at two years of age. Answers from the same 0-100 score questionnaire, with optimal score 100 nine months after enrolment, was also available for 289 of these children at about one year of age. Recurrent bronchial obstruction was used as an asthma proxy. Atopic dermatitis was defined by Hanifin and Rajka criteria and allergic sensitisation by a positive skin prick test. Due to different inclusion criteria, we tested possible interactions with affiliation groups. Associations between QoL and cortisol were analysed by multivariate analyses, stratified by bronchiolitis and control groups due to interaction from affiliation grouping on results. At two years of age, QoL decreased significantly with decreasing cortisol in 8/13 QoL domains in the bronchiolitis group, but only with General health in the controls. The associations in the bronchiolitis group showed 0.06-0.19 percentage points changes per nmol/L cortisol for each of the eight domains (p-values 0.0001-0.034). The associations remained significant but diminished by independently including recurrent bronchial obstruction and atopic dermatitis, but remained unchanged by allergic sensitisation. In the bronchiolitis group only, 7/13 age and gender adjusted QoL domains in one-year old children were lower with lower cortisol levels at two years of age (p = 0.0005-0.04). CONCLUSIONS: At two years, most QoL domains decreased with lower salivary cortisol among children who had been hospitalised for acute bronchiolitis in infancy, but for one domain only among controls. Recurrent bronchial obstruction and to a lesser extent atopic dermatitis, weakened these associations that nevertheless remained significant. After bronchiolitis, lower QoL in one-year old children was associated with lower salivary cortisol at two years. | en_US |
dc.description.sponsorship | The project was supported by a grant to
the first author’s employer, Innlandet Hospital
Trust, (Project no. 150189 to LBR) from a research
fund foundation, Klosterstiftelsen. Klosterstiftelsen
does not have any specific URL, but further
information can be reached at https://www.
purehelp.no/m/company/details/klosterstiftelsen/
982953146. No commercial companies funded the
study or authors. The funders had no role in study
design, data collection and analysis, decision to
publish, or preparation of the manuscript. The
other authors did not receive any specific funding
for this work. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Pone | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.subject | AD, | en_US |
dc.subject | Atopic dermatitis; | en_US |
dc.subject | ITQOL | en_US |
dc.subject | The Infant Toddler Quality of Life Questionnaire; | en_US |
dc.subject | QoL, | en_US |
dc.subject | Health related quality of life | en_US |
dc.title | Quality of life, salivary cortisol and atopic diseases in young children | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2019 Rolfsjord et al.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which
permits unrestricted use, distribution, and reproduction in any medium, provided the original
author and source are credited. | en_US |
dc.source.pagenumber | 1-17 | en_US |
dc.source.volume | 14:e0214040 | en_US |
dc.source.journal | PLOS ONE | en_US |
dc.source.issue | 8 | en_US |
dc.identifier.doi | 10.1371/journal.pone.0214040 | |
dc.identifier.cristin | 1752776 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |