dc.contributor.author | Idland, Ane-Victoria | |
dc.contributor.author | Roser, Sala-Llonch | |
dc.contributor.author | Borza, Tom | |
dc.contributor.author | Watne, Leiv Otto | |
dc.contributor.author | Wyller, Torgeir Bruun | |
dc.contributor.author | Brækhus, Anne | |
dc.contributor.author | Zetterberg, Henrik | |
dc.contributor.author | Blennow, Kaj | |
dc.contributor.author | Walhovd, Kristine B | |
dc.contributor.author | Fjell, Anders Martin | |
dc.date.accessioned | 2018-10-10T13:17:53Z | |
dc.date.available | 2018-10-10T13:17:53Z | |
dc.date.created | 2016-11-07T08:56:09Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Neurobiology of Aging. 2017, 49 138-144. | nb_NO |
dc.identifier.issn | 0197-4580 | |
dc.identifier.uri | http://hdl.handle.net/11250/2567476 | |
dc.description.abstract | Cerebrospinal fluid (CSF) neurofilament light (NFL) is a marker of axonal degeneration. We tested whether CSF NFL levels predict hippocampal atrophy rate in cognitively healthy older adults independently of the established CSF Alzheimer's disease (AD) biomarkers, β-amyloid 1-42, and phosphorylated tau (P-tau). We included 144 participants in a 2-year longitudinal study with baseline CSF measures and 2 magnetic resonance images. Eighty-eight participants had full data available. A subgroup of 36 participants with very low AD risk was also studied. NFL predicted hippocampal atrophy rate independently of age, β-amyloid 1-42, and P-tau. Including NFL, P-tau, and age in the same model, higher NFL and lower P-tau predicted higher hippocampal atrophy (R2 = 0.20, NFL: β = -0.34; p = 0.003; P-tau: β = 0.27; p = 0.009). The results were upheld in the participants with very low AD risk. NFL predicted neurodegeneration in older adults with very low AD probability. We suggest that factors previously shown to be important for brain degeneration in mild cognitive impairment may also impact changes in normal aging, demonstrating that NFL is likely to indicate AD-independent, age-expected neurodegeneration. | nb_NO |
dc.description.sponsorship | The study was mainly funded by the Medical Student Research Program at the University of Oslo and The National Association for Public Health’s dementia research program, Norway. Further, we have received funding from Innlandet Hospital Trust, the Knut and Alice Wallenberg Foundation, the Swedish Research Council, and the Torsten Söderberg Foundation at the Royal Swedish Academy of Sciences. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.subject | Cerebrospinal fluid; | nb_NO |
dc.subject | Hippocampal atrophy rate; | nb_NO |
dc.subject | Magnetic resonance imaging; | nb_NO |
dc.subject | Neurofilament light; | nb_NO |
dc.subject | Normal aging; | nb_NO |
dc.title | CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.rights.holder | Dette verket har følgende lisens: Attribution-NonCommercial-NoDerivatives 4.0 International | nb_NO |
dc.source.pagenumber | 138-144 | nb_NO |
dc.source.volume | 49 | nb_NO |
dc.source.journal | Neurobiology of Aging | nb_NO |
dc.identifier.doi | 10.1016/j.neurobiolaging.2016.09.012 | |
dc.identifier.cristin | 1397850 | |
cristin.unitcode | 1991,9,0,0 | |
cristin.unitname | Div Psykisk helsevern | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |