dc.contributor.author | Chowdhury, Ranadip | |
dc.contributor.author | Taneja, Sunita | |
dc.contributor.author | Bhandari, Nita | |
dc.contributor.author | Kvestad, Ingrid | |
dc.contributor.author | Strand, Tor A | |
dc.contributor.author | Bhan, Maharaj Kishan | |
dc.date.accessioned | 2018-03-28T10:18:52Z | |
dc.date.available | 2018-03-28T10:18:52Z | |
dc.date.created | 2017-09-27T15:13:54Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Nutrition Journal. 2017, 16:59 1-8. | nb_NO |
dc.identifier.issn | 1475-2891 | |
dc.identifier.uri | http://hdl.handle.net/11250/2492308 | |
dc.description.abstract | Abstract
Background
Vitamin-D deficiency has been linked with impaired development in animal studies; however, the evidence from human studies is scanty. Evidence as to whether vitamin-D deficiency during early childhood affects growth is also limited and conflicting. We examined the extent to which vitamin-D deficiency (<10 ng/ml) is associated with neurodevelopment and physical growth in young children.
Methods
We used data from a randomized controlled trial (RCT) of daily folic acid and/ or vitamin B12 supplementation for six months in children aged 6 to 30 months conducted in Delhi, India. We measured vitamin-D status and neurodevelopment by the Ages and Stages Questionnaire-3 (ASQ-3) at 12 to 36 months of age. Multiple logistic and linear regressions were used to examine the association between vitamin-D deficiency at baseline and neurodevelopment and growth 6 months follow-up.
Results
25-hydroxy-vitamin-D (25OHD) concentration was measured at baseline for 960 (96%) children. Of these, 331 (34.5%) children were vitamin-D deficient. The total and subscale (except for the Personal social scale) ASQ-3 scores, were not different between the vitamin-D deficient and non-deficient children. Vitamin-D deficiency was also not associated with physical growth at baseline and at follow -up.
Conclusion
Our data do not support the hypothesis that vitamin-D deficiency is associated with poor growth and neurodevelopment.
Trial registration
NCT00717730 and CTRI/2010/091/001090. Date of registration: 08 October, 2010
Keywords
Vitamin-D – ASQ-3 – Neurodevelopment – Physical growth – Young north Indian children | nb_NO |
dc.description.sponsorship | The study was funded by the Centre for Intervention Science in Maternal and Child Health (CISMAC GRANTS 250216). The implementation of the main trial was supported by grants from the South-Eastern Norway Regional Health Authority (grant no. 2012090) and Thrasher Research Fund (grant no. 9144). | nb_NO |
dc.language.iso | eng | nb_NO |
dc.rights | Navngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/deed.no | * |
dc.subject | Vitamin-D | nb_NO |
dc.subject | ASQ-3 | nb_NO |
dc.subject | Neurodevelopment | nb_NO |
dc.subject | Physical growth | nb_NO |
dc.subject | Young north Indian children | nb_NO |
dc.title | Vitamin-D status and neurodevelopment and growth in young north Indian children: a secondary data analysis | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.rights.holder | Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | nb_NO |
dc.source.pagenumber | 1-8 | nb_NO |
dc.source.volume | 16:59 | nb_NO |
dc.source.journal | Nutrition Journal | nb_NO |
dc.identifier.doi | 10.1186/s12937-017-0285-y | |
dc.identifier.cristin | 1499037 | |
dc.relation.project | Helse Sør-Øst RHF: 2012090 | nb_NO |
dc.relation.project | Norges forskningsråd: 223269 | nb_NO |
cristin.unitcode | 1991,1,2,0 | |
cristin.unitname | Avd Forskning | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |