Blar i Sykehuset Innlandet HF på forfatter "Aaseth, Jan"
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The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases
Hestad, Knut; Alexander, Jan; Rootwelt, Helge; Aaseth, Jan (Peer reviewed; Journal article, 2022)Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several ... -
Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Wågsäter, Dick (Journal article; Peer reviewed, 2017)Background Selenium and coenzyme Q10 is essential for important cellular functions. A low selenium intake is reported from many European countries, and the endogenous coenzyme Q10 production is decreasing in the body with ... -
Significant changes in metabolic profiles after intervention with selenium and coenzyme q10 in an elderly population
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Surowiec, Izabella; Lundstedt-Enkel, Katrin; Lundstedt, Torbjörn (Peer reviewed; Journal article, 2019)Selenium and coenzyme Q10 (SeQ10) are important for normal cellular function. Low selenium intake leads to increased cardiovascular mortality. Intervention with these substances with healthy elderly persons over a period ... -
Significant decrease of von Willebrand factor and plasminogen activator inhibitor-1 by providing supplementation with selenium and coenzyme Q10 to an elderly population with a low selenium status
Alehagen, Urban; Alexander, Jan; Aaseth, Jan; Larsson, A.; Lindahl, T. L. (Peer reviewed; Journal article, 2020)Purpose: Endothelial dysfunction and inflammation are conditions which fuel atherosclerosis and ischaemic heart disease. We have previously reported reduced cardiovascular (CV) mortality following supplementation with ... -
Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly
Alehagen, Urban; Aaseth, Jan; Alexander, Jan; Johansson, Peter (Peer reviewed; Journal article, 2018)Selenium and coenzyme Q10 are both necessary for optimal cell function in the body. The intake of selenium is low in Europe, and the endogenous production of coenzyme Q10 decreases as age increases. Therefore, an intervention ... -
Toxic and Essential Metals in Human Health and Disease 2021
Aaseth, Jan (Others, 2022) -
Xenobiotics, trace metals and genetics in the pathogenesis of tauopathies
Aaseth, Jan; Buha, Aleksandra; Wallace, David R.; Bjørklund, Geir (Peer reviewed; Journal article, 2020)Tauopathies are a disease group characterized by either pathological accumulation or release of fragments of hyperphosphorylated tau proteins originating from the central nervous system. The tau hypotheses of Parkinson’s ...