Browsing SIHF Open Archive by Author "Engedal, Knut"
Now showing items 1-20 of 24
-
A 52 month follow-up of functional decline in nursing home residents - Degree of dementia contributes
Helvik, Anne-Sofie; Engedal, Knut; Saltyte Benth, Jurate; Selbæk, Geir (Journal article; Peer reviewed, 2014)Background: Few have studied how personal activities of daily living (P-ADL) develop over time in nursing home residents with dementia. Thus, the aim was to study variables associated with the development of P-ADL functioning ... -
Alcohol and prescribed psychotropic drug use among patients admitted to a department of old age psychiatry in Norway
Johannessen, Aud; Engedal, Knut; Larsen, Marianne; Lillehovde, Elin Johnsen; Stelander, Line; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2017)Background: Although alcohol and prescribed psychotropic drug use has increased among older people, the usefulness of information provided about these substances in patients’ referrals to departments of old-age psychiatry ... -
Association between vascular comorbidity and progression of Alzheimer's disease: a two-year observational study in Norwegian memory clinics
Eldholm, Rannveig Sakshaug; Persson, Karin Ester Torun; Barca, Maria Lage; Knapskog, Anne Brita; Cavallin, Lena; Engedal, Knut; Selbæk, Geir; Skovlund, Eva; Saltvedt, Ingvild (Peer reviewed; Journal article, 2018)Abstract BACKGROUND: Vascular risk factors increase the risk of Alzheimer's disease (AD), but there is limited evidence on whether comorbid vascular conditions and risk factors have an impact on disease progression. The ... -
Being stuck in a vice: The process of coping with severe depression in late life
Björklöf, Guro Hanevold; Kirkevold, Marit; Engedal, Knut; Selbæk, Geir; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2015)Articles describing older persons’ experiences of coping with severe depression are, to our knowledge, lacking. This article is methodologically grounded in phenomenological hermeneutics, inspired by Paul Ricoeur, and ... -
Cortisol levels among older people with and without depression and dementia
Barca, Maria Lage; Eldholm, Rannveig Sakshaug; Persson, Karin Ester Torun; Björklöf, Guro Hanevold; Borza, Tom; Telenius, Elisabeth Wiken; Knapskog, Anne-Brita; Brækhus, Anne; Saltvedt, Ingvild; Selbæk, Geir; Engedal, Knut (Peer reviewed; Journal article, 2018)ABSTRACTCortisol dysregulation has been reported in dementia and depression. Cortisol levels and its associates were investigated among older people living at home and in nursing homes, in a cross-sectional study. A sample ... -
Cost analysis of day care centres in Norway
Vossius, Corinna Elisabeth; Selbæk, Geir; Saltyte Benth, Jurate; Wimo, A.; Engedal, Knut; Kirkevold, Øyvind; Rokstad, Anne Marie Mork (Journal article; Peer reviewed, 2019)Background: Day care services aim to offer meaningful activities and a safe environment for the attendees and a respite for family caregivers while being cost effective. This study compares the use of formal and informal ... -
Distinguishing early and late brain aging from the Alzheimer's disease spectrum: Consistent morphological patterns across independent samples
Doan, Nhat Trung; Engvig, Andreas; Zaske, Krystal; Persson, Karin; Lund, Martina Jonette; Kaufmann, Tobias; Còrdova Palomera, Aldo; Alnæs, Dag; Moberget, Torgeir; Brækhus, Anne; Barca, Maria Lage; Nordvik, Jan Egil; Engedal, Knut; Agartz, Ingrid; Selbæk, Geir; Andreassen, Ole Andreas; Westlye, Lars Tjelta (Journal article; Peer reviewed, 2017)Abstract Alzheimer's disease (AD) is a debilitating age-related neurodegenerative disorder. Accurate identification of individuals at risk is complicated as AD shares cognitive and brain features with aging. We applied ... -
Factors associated with alcohol consumption and prescribed drugs with addiction potential among older women and men – the Nord-Trøndelag health study (HUNT2 and HUNT3), Norway, a population-based longitudinal study
Tevik, Kjerstin Elisabeth; Selbæk, Geir; Engedal, Knut; Seim, Arnfinn; Krokstad, Steinar; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2019)BACKGROUND: Little is known about factors associated with alcohol consumption and use of drugs with addiction potential in older adults. The aim of this study was to explore the association between socio-demographic ... -
Health-related quality of life in older depressed psychogeriatric patients: one year follow-up
Helvik, Anne-Sofie; Corazzini, Kirsten; Selbæk, Geir; Björklöf, Guro Hanevold; Laks, Jerson; Saltyte Benth, Jurate; Østbye, Truls; Engedal, Knut (Peer reviewed; Journal article, 2016)Background: Knowledge about long-term change in health related quality of life (HQoL) among older adults after hospitalization for treatment of depression has clinical relevance. The aim was firstly to describe the change ... -
Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci
Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fredrik; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas (Peer reviewed; Journal article, 2018)A large fraction of genetic risk factors for Alzheimer's Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) ... -
Mortality in older adults with frequent alcohol consumption and use of drugs with addiction potential – The Nord Trøndelag Health Study 2006-2008 (HUNT3), Norway, a population-based study
Tevik, Kjerstin Elisabeth; Selbæk, Geir; Engedal, Knut; Seim, Arnfinn; Krokstad, Steinar; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2019)BACKGROUND: The aim of this study was to investigate whether frequent drinking, use of drugs with addiction potential and the possible combination of frequent drinking and use of prescribed drugs with addiction potential ... -
MRI-assessed atrophy subtypes in Alzheimer’s disease and the cognitive reserve hypothesis
Persson, Karin; Eldholm, Rannveig Sakshaug; Barca, Maria Lage; Cavallin, Lena; Ferreira, Daniel; Knapskog, Anne Brita; Selbæk, Geir; Brækhus, Anne; Saltvedt, Ingvild; Westman, Eric; Engedal, Knut (Journal article; Peer reviewed, 2017)Background/Aims MRI assessment of the brain has demonstrated four different patterns of atrophy in patients with Alzheimer’s disease dementia (AD): typical AD, limbic-predominant AD, hippocampal-sparing AD, and a subtype ... -
MRI-based classification models in prediction of mild cognitive impairment and dementia in late-life depression
Lebedeva, Aleksandra K.; Westman, Eric; Borza, Tom; Beyer, Mona K.; Engedal, Knut; Aarsland, Dag; Selbæk, Geir; Håberg, Asta (Journal article; Peer reviewed, 2017)Objective: Late-life depression (LLD) is associated with development of different types of dementia. Identification of LLD patients, who will develop cognitive decline, i.e., the early stage of dementia would help to ... -
Persistent use of psychotropic drugs in nursing home residents in Norway
Helvik, Anne-Sofie; Saltyte Benth, Jurate; Wu, Bei; Engedal, Knut; Selbæk, Geir (Journal article; Peer reviewed, 2017)Background The prevalence of psychotropic drug (PTD) use in NH residents is high, but few have explored prevalence and persistency in PTD in NH residents and factors associated with persistency. This at the same time as ... -
Quality of life of family carers of persons with young-onset compared to late-onset dementia
Hvidsten, Lara H. Thomasgaard; Engedal, Knut; Selbæk, Geir; Wyller, Torgeir Bruun; Saltyte Benth, Jurate; Bruvik, Frøydis Kristine; Kersten, Hege (Journal article; Peer reviewed, 2019)Abstract OBJECTIVES: To compare quality of life (QOL) of family carers of persons with young- (YOD) to late-onset dementia (LOD). METHODS: This was a cross-sectional comparison of 88 carers of persons with YOD and ... -
Resource Use and Disease Course in dementia - Nursing Home (REDIC-NH), a longitudinal cohort study; design and patient characteristics at admission to Norwegian nursing homes
Røen, Irene Mari; Selbæk, Geir; Kirkevold, Øyvind; Engedal, Knut; Testad, Ingelin; Bergh, Sverre (Journal article, 2017)Background Earlier studies of nursing home patients show a high prevalence of dementia, neuropsychiatric symptoms (NPS), pain, and dependency in activities of daily living. The REDIC-NH cohort was set up to study the disease ... -
Severity of Neuropsychiatric Symptoms in Nursing Home Residents
Helvik, Anne-Sofie; Engedal, Knut; Wu, Bei; Saltyte Benth, Jurate; Corazzini, Kirsten; Røen, Irene Mari; Selbæk, Geir (Peer reviewed; Journal article, 2016)We aimed at assessing time shift in the severity of neuropsychiatric symptoms (NPS) in nursing home residents between 2004/2005 and 2010/2011 and associations between NPS and socio-demographic variables, physical health ... -
Survival and years of life lost in various aetiologies of dementia, mild cognitive impairment (MCI) and subjective cognitive decline (SCD) in Norway
Strand, Bjørn Heine; Knapskog, Anne Brita; Edwin, Trine Holt; Amland, Rachel; Mjørud, Marit; Bjertness, Espen; Engedal, Knut; Selbæk, Geir (Journal article; Peer reviewed, 2018)Abstract INTRODUCTION: Alzheimer's disease patients are reported to have higher survival rate compared to patients with vascular dementia or dementia with Lewy bodies. There is a paucity of studies investigating ... -
The impact of attending day care designed for home-dwelling people with dementia on nursing home admission : a 24-month controlled study
Rokstad, Anne Marie Mork; Engedal, Knut; Kirkevold, Øyvind; Saltyte Benth, Jurate; Selbæk, Geir (Journal article; Peer reviewed, 2018)Background: Day care services offer meaningful activities, a safe environment for attendees and respite for family caregivers while being expected to delay the need for nursing home (NH) admission. However, previous research ... -
The Relationships among Tryptophan, Kynurenine, Indoleamine 2,3-Dioxygenase, Depression, and Neuropsychological Performance
Hestad, Knut; Engedal, Knut; Whist, Jon Elling; Farup, Per Grønaas (Journal article; Peer reviewed, 2017)It has been suggested that the metabolic enzyme indoleamine 2,3-dioxygenase (IDO) is a biological mediator of inflammation related to the psychopathology of depression, with a Kynurenine (KYN) increase in the Tryptophan ...