Browsing SIHF Open Archive by Author "Alexander, Jan"
Now showing items 1-13 of 13
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Arsenic toxicity: Molecular targets and therapeutic agents
Nurchi, Valeria Marina; Djordjevic, Aleksandra Buha; Crisponi, Guido; Alexander, Jan; Bjørklund, Geir; Aaseth, Jan (Peer reviewed; Journal article, 2020)High arsenic (As) levels in food and drinking water, or under some occupational conditions, can precipitate chronic toxicity and in some cases cancer. Millions of people are exposed to unacceptable amounts of As through ... -
Benefit and risk assessment of fish in the Norwegian diet - Scientific Opinion of the Steering Committee of the Norwegian Scientific Committee for Food and Environment
Andersen, Lene Frost; Berstad, Paula; Bukhvalova, Barbara Alexandra; Carlsen, Monica Hauger; Dahl, Lisbeth Jane; Goksøyr, Anders; Jakobsen, Lea Sletting; Knutsen, Helle Katrine; Kvestad, Ingrid; Lillegaard, Inger Therese Laugsand; Mangschou, Bente; Meyer, Haakon Eduard; Parr, Christine Louise; Rakkestad, Kirsten Eline; Rasinger, Josef; Sengupta, Sayantan; Skeie, Guri; Starrfelt, Jostein; Ulven, Stine Marie; Agdestein, Angelika; Bodin, Johanna Eva; Bruzell, Ellen Merete; Elvevoll, Edel O.; Hemre, Gro Ingunn; Hessen, Dag Olav; Husøy, Trine; Krogdahl, Åshild; Nilsen, Asbjørn Magne; Skjerdal, Olaug Taran; Steffensen, Inger-Lise; Strand, Tor Arne; Vandvik, Vigdis; Velle, Gaute; Wasteson, Yngvild; Alexander, Jan (Peer reviewed; Journal article, 2022)In 2006, VKM published “A comprehensive assessment of fish and other seafood in the Norwegian diet”. The assessment supported the recommendation from Norwegian Health authorities to eat more fish both for dinner and on ... -
Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: a subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK
Alehagen, Urban; Alexander, Jan; Aaseth, Jan; Larsson, Anders (Journal article; Peer reviewed, 2019)Background: Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons ... -
Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10. A prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Brismar, Kerstin (Peer reviewed; Journal article, 2017)Abstract Background Insulin-like growth factor-1(IGF-1) has a multitude of effects besides cell growth and metabolism. Reports also indicate anti-inflammatory and antioxidative effects. The concentrations of IGF-1 ... -
Increased SIRT1 Concentration Following Four Years of Selenium and Q<inf>10</inf> Intervention Associated with Reduced Cardiovascular Mortality at 10-Year Follow-Up—Sub-Study of a Previous Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial
Opstad, Trine Baur; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Seljeflot, Ingebjørg; Alehagen, Urban (Peer reviewed; Journal article, 2023)Background: Selenium and coenzyme Q10 (SeQ10) possess antioxidant and anti-inflammatory properties, potentially mediated via Sirtuin1 (SIRT1). We aimed to investigate the influence of a SeQ10 intervention on SIRT1 ... -
Matproduksjon, mattrygghet og miljø - innspill om kunnskapsbehov til gjennomføringen av det grønne skiftet - Uttalelse fra hovedkomiteen i Vitenskapskomiteen for mat og miljø (VKM)
Alexander, Jan; Aasmo-Finne, Merethe; Agdestein, Angelika; Bodin, Johanna Eva; Bruzell, Ellen Merete; Elvevoll, Edel O.; Hemre, Gro Ingunn; Hessen, Dag Olav; Hofshagen, Merete; Husøy, Trine; Knutsen, Helle Katrine; Krogdahl, Åshild; Mathisen, Gro Haarklou; Nilsen, Asbjørn Magne; Rafoss, Trond; Skjerdal, Olaug Taran; Steffensen, Inger-Lise Karin; Strand, Tor Arne; Vandvik, Vigdis; Velle, Gaute; Wasteson, Yngvild (Peer reviewed; Journal article, 2022)Denne rapporten er utarbeidet av Vitenskapskomiteen for mat og miljø (VKM), en uavhengig, tverrfaglig komité som utarbeider kunnskapsgrunnlag for den norske mat- og miljøforvaltningen på områdene matproduksjon, mattrygghet ... -
Microplastics; occurrence, levels and implications for environment and human health related to food. Scientific opinion of the Scientific Steering Committee of the Norwegian Scientific Committee for Food and Environment
Skåre, Janneche Utne; Alexander, Jan; Haave, Marte; Jakubowicz, Ignacy; Knutsen, Helle Katrine; Lusher, Amy; Ogonowski, Martin; Rakkestad, Kirsten Eline; Skaar, Ida; Sverdrup, Line Emilie; Wagner, Martin; Agdestein, Angelika; Bodin, Johanna Eva; Elvevoll, Edel O.; Hemre, Gro Ingunn; Hessen, Dag Olav; Hofshagen, Merete; Husøy, Trine; Krogdahl, Åshild; Nilsen, Asbjørn Magne; Rafoss, Trond; Skjerdal, Olaug Taran; Steffensen, Inger-Lise; Strand, Tor A; Vandvik, Vigdis; Wasteson, Yngvild (VKM Report;, Others, 2019)Summary The steering committee of VKM has self-initiated a mandate for an opinion on microplastics based on recently published international and/or national reports complemented with literature from December 2016 to ... -
Postoperative Osteoporosis in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy
Aaseth, Jan; Alexander, Jan (Peer reviewed; Journal article, 2023)Obesity has become a worldwide epidemic accompanied by adverse health effects. The limited efficiency of traditional weight reduction regimens has led to a substantial increase in the use of bariatric surgery. Today, sleeve ... -
The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases
Hestad, Knut; Alexander, Jan; Rootwelt, Helge; Aaseth, Jan (Peer reviewed; Journal article, 2022)Emerging evidence suggests that neuroinflammation is involved in both depression and neurodegenerative diseases. The kynurenine pathway, generating metabolites which may play a role in pathogenesis, is one of several ... -
Significant changes in circulating microRNA by dietary supplementation of selenium and coenzyme Q10 in healthy elderly males. A subgroup analysis of a prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Wågsäter, Dick (Journal article; Peer reviewed, 2017)Background Selenium and coenzyme Q10 is essential for important cellular functions. A low selenium intake is reported from many European countries, and the endogenous coenzyme Q10 production is decreasing in the body with ... -
Significant changes in metabolic profiles after intervention with selenium and coenzyme q10 in an elderly population
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Surowiec, Izabella; Lundstedt-Enkel, Katrin; Lundstedt, Torbjörn (Peer reviewed; Journal article, 2019)Selenium and coenzyme Q10 (SeQ10) are important for normal cellular function. Low selenium intake leads to increased cardiovascular mortality. Intervention with these substances with healthy elderly persons over a period ... -
Significant decrease of von Willebrand factor and plasminogen activator inhibitor-1 by providing supplementation with selenium and coenzyme Q10 to an elderly population with a low selenium status
Alehagen, Urban; Alexander, Jan; Aaseth, Jan; Larsson, A.; Lindahl, T. L. (Peer reviewed; Journal article, 2020)Purpose: Endothelial dysfunction and inflammation are conditions which fuel atherosclerosis and ischaemic heart disease. We have previously reported reduced cardiovascular (CV) mortality following supplementation with ... -
Still reduced cardiovascular mortality 12 years after supplementation with selenium and coenzyme Q10 for four years: A validation of previous 10-year follow-up results of a prospective randomized double-blind placebo-controlled trial in elderly
Alehagen, Urban; Aaseth, Jan; Alexander, Jan; Johansson, Peter (Peer reviewed; Journal article, 2018)Selenium and coenzyme Q10 are both necessary for optimal cell function in the body. The intake of selenium is low in Europe, and the endogenous production of coenzyme Q10 decreases as age increases. Therefore, an intervention ...