Browsing SIHF Open Archive by Author "Aaseth, Jan"
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Arsenic toxicity: Molecular targets and therapeutic agents
Nurchi, Valeria Marina; Djordjevic, Aleksandra Buha; Crisponi, Guido; Alexander, Jan; Bjørklund, Geir; Aaseth, Jan (Peer reviewed; Journal article, 2020)High arsenic (As) levels in food and drinking water, or under some occupational conditions, can precipitate chronic toxicity and in some cases cancer. Millions of people are exposed to unacceptable amounts of As through ... -
Cadmium, lead and mercury in Norwegian obese patients before and 12 months after bariatric surgery
Mikalsen, Solveig Meyer; Monsen, Anne Lise Bjørke; Flaten, Trond Peder; Whist, Jon Elling; Aaseth, Jan (Peer reviewed; Journal article, 2019)Purpose Previous studies have suggested a role for the toxic elements lead (Pb), mercury (Hg) and cadmium (Cd) in the development of insulin resistance and hypertension. Increased blood Pb levels have been reported after ... -
Cerebral hypoperfusion in autism spectrum disorder
Bjørklund, Geir; Kern, Janet K; Urbina, Mauricio A.; Saad, Khaled; El-Houfey, Amira A.; Geier, David A.; Chirumbolo, Salvatore; Geier, Mark R.; Mehta, Jyutika A.; Aaseth, Jan (Peer reviewed; Journal article, 2018)Cerebral hypoperfusion, or insufficient blood flow in the brain, occurs in many areas of the brain in patients diagnosed with autism spectrum disorder (ASD). Hypoperfusion was demonstrated in the brains of individuals with ... -
Chelation Combination - A Strategy to Mitigate the Neurotoxicity of Manganese, Iron, and Copper?
Aaseth, Jan; Nurchi, Valeria M. (Peer reviewed; Journal article, 2022)The chelating thiol dimercaptosuccinate (DMSA) and the traditional agent D-penicillamine (PSH) are effective in enhancing the urinary excretion of copper (Cu) and lead (Pb) in poisoned individuals. However, DMSA, PSH, EDTA ... -
Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach
Bjørklund, Geir; Dadar, Maryam; Pen, Joeri J.; Chirumbolo, Salvatore; Aaseth, Jan (Peer reviewed; Journal article, 2019)Chronic fatigue syndrome (CFS) is known as a multi-systemic and complex illness, which induces fatigue andlong-term disability in educational, occupational, social, or personal activities. The diagnosis of this disease ... -
Circulating Lipoproteins in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy
Aaseth, Jan; Rootwelt, Helge; Retterstøl, Kjetil; Hestad, Knut; Farup, Per Grønaas (Peer reviewed; Journal article, 2022)The efficacy of various bariatric procedures on the mitigation of the obese dyslipidemia remains debated, and the impact of these measures on lipoprotein(a) (Lp(a)) levels is unknown. In this study we aimed to compare the ... -
Decrease in inflammatory biomarker concentration by intervention with selenium and coenzyme Q10: a subanalysis of osteopontin, osteoprotergerin, TNFr1, TNFr2 and TWEAK
Alehagen, Urban; Alexander, Jan; Aaseth, Jan; Larsson, Anders (Journal article; Peer reviewed, 2019)Background: Inflammation is central to the pathogenesis of many diseases. Supplementation with selenium and coenzyme Q10 has been shown to reduce cardiovascular mortality, and increase cardiac function in elderly persons ... -
Dose-response relationship between dietary magnesium intake, serum magnesium concentration and risk of hypertension: a systematic review and meta-analysis of prospective cohort studies
Han, Hedong; Fang, Xin; Wei, Xin; Liu, Yuzhou; Jin, Zhicao; Chen, Qi; Fan, Zhongjie; Aaseth, Jan; Hiyoshi, Ayako; He, Jia; Cao, Yang (Journal article; Peer reviewed, 2017)Background The findings of prospective cohort studies are inconsistent regarding the association between dietary magnesium intake and serum magnesium concentration and the risk of hypertension. We aimed to review the ... -
Essential trace elements in Norwegian obese patients before and 12 months after Roux-en-Y gastric bypass surgery: Copper, manganese, selenium and zinc
Mikalsen, Solveig Meyer; Aaseth, Jan; Flaten, Trond Peder; Whist, Jon Elling; Monsen, Anne Lise Bjørke (Peer reviewed; Journal article, 2020)Objectives: The objective of the present study was to assess trace element status in morbidly obese subjects before and one year after Roux-en-Y gastric bypass (RYGB) in order to identify possible deficiencies. Methods: ... -
Gadolinium in Medical Imaging - Usefulness, Toxic Reactions and Possible Countermeasures - A Review
Blomqvist, Lennart; Nordberg, Gunnar F.; Nurchi, Valeria M.; Aaseth, Jan (Peer reviewed; Journal article, 2022)Gadolinium (Gd) is one of the rare-earth elements. The properties of its trivalent cation (Gd3+) make it suitable to serve as the central ion in chelates administered intravenously to patients as a contrast agent in magnetic ... -
Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues
Skalny, Anatoly V.; Aschner, Michael; Lei, Xin Gen; Gritsenko, Viktor A.; Santamaria, Abel; Alekseenko, Svetlana I.; Prakash, Nagaraja Tejo; Chang, Jung-Su; Sizova, Elena A.; Chao, Jane C.J.; Aaseth, Jan; Tinkov, Alexey A. (Peer reviewed; Journal article, 2021)The objective of the present study was to review the existing data on the association between Zn status and characteristics of gut microbiota in various organisms and the potential role of Zn-induced microbiota in modulating ... -
Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease
Skalny, Anatoly V.; Kopylov, Philippe Yu; Paoliello, Monica M.B.; Chang, Jung-Su; Aschner, Michael; Bobrovnitsky, Igor P.; Chao, Jane C.-J.; Aaseth, Jan; Chebotarev, Sergei N.; Tinkov, Alexey A. (Peer reviewed; Journal article, 2021)Abstract The objective of the present study was to evaluate hair toxic metal levels in patients with obesity and/or coronary heart disease (CHD). Following a 2 × 2 factorial design, subjects without CHD were grouped into ... -
Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10. A prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens
Alehagen, Urban; Johansson, Peter; Aaseth, Jan; Alexander, Jan; Brismar, Kerstin (Peer reviewed; Journal article, 2017)Abstract Background Insulin-like growth factor-1(IGF-1) has a multitude of effects besides cell growth and metabolism. Reports also indicate anti-inflammatory and antioxidative effects. The concentrations of IGF-1 ... -
Increased SIRT1 Concentration Following Four Years of Selenium and Q<inf>10</inf> Intervention Associated with Reduced Cardiovascular Mortality at 10-Year Follow-Up—Sub-Study of a Previous Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial
Opstad, Trine Baur; Alexander, Jan; Aaseth, Jan; Larsson, Anders; Seljeflot, Ingebjørg; Alehagen, Urban (Peer reviewed; Journal article, 2023)Background: Selenium and coenzyme Q10 (SeQ10) possess antioxidant and anti-inflammatory properties, potentially mediated via Sirtuin1 (SIRT1). We aimed to investigate the influence of a SeQ10 intervention on SIRT1 ... -
Iron Deficiency in Obesity and After Bariatric Surgery
Bjørklund, Geir; Peana, Massimiliano; Pivina, Lyudmila; Dosa, Alexandru; Aaseth, Jan; Semenova, Yuliya; Chirumbolo, Salvatore; Medici, Serenella; Dadar, Maryam; Costea, Daniel-Ovidiu (Peer reviewed; Journal article, 2021)Iron deficiency (ID) is particularly frequent in obese patients due to increased circulating levels of acute-phase reactant hepcidin and adiposity-associated inflammation. Inflammation in obese subjects is closely related ... -
Lead poisoning among opium users in Iran: an emerging health hazard
Hayatbakhsh, Mohammad Mahdi; Oghabian, Zohreh; Conlon, Elvira; Nakhaee, Samaneh; Amirabadizadeh, Ali Reza; Zahedi, Mohammad Javad; Moghadam, Sodief Darvish; Ahmadi, Bighan; Soroush, Somayeh; Aaseth, Jan; Mehrpour, Omid (Journal article; Peer reviewed, 2017)Background Lead (Pb) poisoning among people using opium has been an increasing problem in Iran. The present study highlights the clinical effects of lead toxicity associated with opium use in Iran, Kerman province. Methods ... -
Medical therapy of patients contaminated with radioactive cesium or iodine
Aaseth, Jan; Nurchi, Valeria Marina; Andersen, Ole (Peer reviewed; Journal article, 2019)Follow-up studies after the Chernobyl and Fukushima accidents have shown that 137Cs and 131I made up the major amount of harmful contaminants in the atmospheric dispersion and fallout. Other potential sources for such ... -
Mercury exposure and its effects on fertility and pregnancy outcome
Bjørklund, Geir; Chirumbolo, Salvatore; Dadar, Maryam; Pivina, Lyudmila; Lindh, Ulf; Butnariu, Monica; Aaseth, Jan (Peer reviewed; Journal article, 2019)Mercury (Hg), a highly toxic environmental pollutant, shows harmfulness which still represents a big concern for human health, including hazards to fertility and pregnancy outcome. Research has shown that Hg could induce ... -
Postoperative Osteoporosis in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy
Aaseth, Jan; Alexander, Jan (Peer reviewed; Journal article, 2023)Obesity has become a worldwide epidemic accompanied by adverse health effects. The limited efficiency of traditional weight reduction regimens has led to a substantial increase in the use of bariatric surgery. Today, sleeve ... -
Prevention of progression in Parkinson’s disease
Aaseth, Jan; Dusek, Petr; Roos, Per M. (Journal article; Peer reviewed, 2018)Environmental influences affecting genetically susceptible individuals seem to contribute significantly to the development of Parkinson’s disease (PD). Xenobiotic exposure including transitional metal deposition into ...