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dc.contributor.authorSkalny, Anatoly V.
dc.contributor.authorAschner, Michael
dc.contributor.authorLei, Xin Gen
dc.contributor.authorGritsenko, Viktor A.
dc.contributor.authorSantamaria, Abel
dc.contributor.authorAlekseenko, Svetlana I.
dc.contributor.authorPrakash, Nagaraja Tejo
dc.contributor.authorChang, Jung-Su
dc.contributor.authorSizova, Elena A.
dc.contributor.authorChao, Jane C.J.
dc.contributor.authorAaseth, Jan
dc.contributor.authorTinkov, Alexey A.
dc.date.accessioned2024-05-03T14:17:47Z
dc.date.available2024-05-03T14:17:47Z
dc.date.created2022-01-24T12:43:20Z
dc.date.issued2021
dc.identifier.citationInternational Journal of Molecular Sciences. 2021, 22 (23), .
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/11250/3129082
dc.description.abstractThe objective of the present study was to review the existing data on the association between Zn status and characteristics of gut microbiota in various organisms and the potential role of Zn-induced microbiota in modulating systemic effects. The existing data demonstrate a tight relationship between Zn metabolism and gut microbiota as demonstrated in Zn deficiency, supplementation, and toxicity studies. Generally, Zn was found to be a significant factor for gut bacteria biodiversity. The effects of physiological and nutritional Zn doses also result in improved gut wall integrity, thus contributing to reduced translocation of bacteria and gut microbiome metabolites into the systemic circulation. In contrast, Zn overexposure induced substantial alterations in gut microbiota. In parallel with intestinal effects, systemic effects of Zn-induced gut microbiota modulation may include systemic inflammation and acute pancreatitis, autism spectrum disorder and attention deficit hyperactivity disorder, as well as fetal alcohol syndrome and obesity. In view of both Zn and gut microbiota, as well as their interaction in the regulation of the physiological functions of the host organism, addressing these targets through the use of Zn-enriched probiotics may be considered an effective strategy for health management. Keywords: Escherichia coli; gut microbiota; lipopolysaccharide; probiotic; zinc.
dc.language.isoeng
dc.relation.urihttps://www.mdpi.com/1422-0067/22/23/13074
dc.titleGut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.source.pagenumber16
dc.source.volume22
dc.source.journalInternational Journal of Molecular Sciences
dc.source.issue23
dc.identifier.doi10.3390/ijms222313074
dc.identifier.cristin1988502
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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