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dc.contributor.authorBakke, Laura A. Wortinger
dc.contributor.authorEndestad, Tor
dc.contributor.authorMelinder, Annika Maria D
dc.contributor.authorØie, Merete Glenne
dc.contributor.authorSulheim, Dag
dc.contributor.authorFagermoen, Frode Even
dc.contributor.authorWyller, Vegard Bruun
dc.identifier.citationJournal of Clinical and Experimental Neuropsychology. 2017, 39 (4), 355-368.en_US
dc.descriptionCitation: Laura Anne Wortinger, Tor Endestad, Annika Maria D Melinder, Merete Glenne Øie, Dag Sulheim, Even Fagermoen & Vegard Bruun Wyller (2016) Emotional conflict processing in adolescent chronic fatigue syndrome: A pilot study using functional magnetic resonance imaging, Journal of Clinical and Experimental Neuropsychology, 39:4, 355-368, DOI: 10.1080/13803395.2016.1230180en_US
dc.description.abstractIntroduction: Studies of neurocognition suggest that abnormalities in cognitive control contribute to the pathophysiology of chronic fatigue syndrome (CFS) in adolescents, yet these abnormalities remain poorly understood at the neurobiological level. Reports indicate that adolescents with CFS are significantly impaired in conflict processing, a primary element of cognitive control. Method: In this study, we examine whether emotional conflict processing is altered on behavioral and neural levels in adolescents with CFS and a healthy comparison group. Fifteen adolescent patients with CFS and 24 healthy adolescent participants underwent functional magnetic resonance imaging (fMRI) while performing an emotional conflict task that involved categorizing facial affect while ignoring overlaid affect labeled words. Results: Adolescent CFS patients were less able to engage the left amygdala and left midposterior insula (mpINS) in response to conflict than the healthy comparison group. An association between accuracy interference and conflict-related reactivity in the amygdala was observed in CFS patients. A relationship between response time interference and conflict-related reactivity in the mpINS was also reported. Neural responses in the amygdala and mpINS were specific to fatigue severity. Conclusions: These data demonstrate that adolescent CFS patients displayed deficits in emotional conflict processing. Our results suggest abnormalities in affective and cognitive functioning of the salience network, which might underlie the pathophysiology of adolescent CFS.en_US
dc.description.sponsorshipThis study is part of the NorCAPITAL-project (The Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial) (Clinical Trials ID: NCT01040429). It was conducted at the Department of Pediatrics, Oslo University Hospital, Norway, which is a national referral center for young CFS patients. The current study is based on cross-sectional data collected during the first clinical in-hospital day of NorCAPITAL, from March 2010 to May 2012. All participants received a gift-card worth NOK 200. This work was supported by the Norwegian Research Council (VBW, grant number 228874); 498 Health South–East Hospital Trust (VBW); and the University of Oslo (VBW).en_US
dc.publisherTaylor and Francisen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.subjectchronic fatigue syndromeen_US
dc.subjectfunctional MRIen_US
dc.subjectcognitive controlen_US
dc.titleEmotional conflict processing in adolescent chronic fatigue syndrome: A pilot study using functional magnetic resonance imagingen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2017 Taylor & Francisen_US
dc.source.journalJournal of Clinical and Experimental Neuropsychologyen_US
cristin.unitnameDiv Lillehammer
cristin.unitnameAvd Barn

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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