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dc.contributor.authorHestad, Knut
dc.contributor.authorEngedal, Knut
dc.contributor.authorSelbæk, Geir
dc.contributor.authorStrand, Bjørn Heine
dc.date.accessioned2022-05-02T12:48:44Z
dc.date.available2022-05-02T12:48:44Z
dc.date.created2021-05-19T08:23:57Z
dc.date.issued2021
dc.identifier.citationBrain and Behavior. 2021:e02166, DOI: https://doi.org/10.1002/brb3.2166en_US
dc.identifier.issn2162-3279
dc.identifier.urihttps://hdl.handle.net/11250/2993664
dc.description.abstractObjective: It is unknown whether systolic blood pressure (SBP) drop is part of the normal aging process or due to the onset of dementia for some people. SBP drop is referring to the decrease in blood pressure often seen before death. Thus, the aim of this study was to examine whether SBP at time of diagnosis of dementia, mild cognitive impairment, or subjective cognitive decline was associated with years prior to death, and whether these associations were modified by diagnoses, age, and sex. Methods: Participants were 2,236 patients from the Norwegian Registry of Persons Assessed for Cognitive Symptoms (NorCog), who died during follow-up (2009-2017) for whom we had valid blood pressure measurements. Mean age at diagnosis was 77.5 years (SD 8.3), and patients were followed for an average of 3.9 years (SD 2.2, maximum 10.5 years). The patients had subjective cognitive decline (95), mild cognitive impairment (573), dementia (1,401), or no diagnoses related to cognitive deficits (167). SBP as dependent variable was regressed against years prior to death. Results: In men, SBP was 1.8 mmHg lower per year closer to death (p < .01), and this trend was linear without any acceleration. This association between years prior to death and SBP in men was not modified by age, year of diagnosis, or diagnosis. There was no such association in women. Conclusion: SBP was significantly lower for those diagnosed close to death in men, but not in women. This association was not modified by either age or onset of diagnosis. Thus, the lowering of SBP is more related to closeness to death and sex than to dementia or age. The downward trend was linear all 10 years prior to death, with no acceleration closer to death.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.subjectaging,en_US
dc.subjectblood pressure,en_US
dc.subjectdeath,en_US
dc.subjectdementia,en_US
dc.subjectmild cognitive impairment,en_US
dc.subjectsex,en_US
dc.subjectsex differences,en_US
dc.subjectsystolicen_US
dc.titleBlood pressure in dementia, mild cognitive impairment, and subjective cognitive decline related to time of deathen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holderThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLCen_US
dc.source.pagenumber1-7en_US
dc.source.volume11en_US
dc.source.journalBrain and Behavioren_US
dc.source.issue7en_US
dc.identifier.doi10.1002/brb3.2166
dc.identifier.cristin1910636
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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