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dc.contributor.authorTorske, Tonje
dc.contributor.authorNærland, Terje
dc.contributor.authorBettella, Francesco
dc.contributor.authorBjella, Thomas
dc.contributor.authorMalt, Eva Albertsen
dc.contributor.authorHøyland, Anne Lise
dc.contributor.authorStenberg, Nina
dc.contributor.authorØie, Merete Glenne
dc.contributor.authorAndreassen, Ole Andreas
dc.identifier.citationAutism Res . 2020 Feb;13(2):207-220. doi: 10.1002/aur.2207. Epub 2019 Sep 30.en_US
dc.description.abstractAutism spectrum disorder (ASD) and other neurodevelopmental disorders (NDs) are behaviorally defined disorders with overlapping clinical features that are often associated with higher-order cognitive dysfunction, particularly executive dysfunction. Our aim was to determine if the polygenic score (PGS) for ASD is associated with parent-reported executive dysfunction in everyday life using the Behavior Rating Inventory of Executive Function (BRIEF). Furthermore, we investigated if PGS for general intelligence (INT) and attention deficit/hyperactivity disorder (ADHD) also correlate with BRIEF. We included 176 children, adolescents and young adults aged 5-22 years with full-scale intelligence quotient (IQ) above 70. All were admitted for clinical assessment of ASD symptoms and 68% obtained an ASD diagnosis. We found a significant difference between low and high ASD PGS groups in the BRIEF behavior regulation index (BRI) (P = 0.015, Cohen's d = 0.69). A linear regression model accounting for age, sex, full-scale IQ, Social Responsiveness Scale (SRS) total score, ASD, ADHD and INT PGS groups as well as genetic principal components, significantly predicted the BRI score; F(11,130) = 8.142, P < 0.001, R2 = 0.41 (unadjusted). Only SRS total (P < 0.001), ASD PGS 0.1 group (P = 0.018), and sex (P = 0.022) made a significant contribution to the model. This suggests that the common ASD risk gene variants have a stronger association to behavioral regulation aspects of executive dysfunction than ADHD risk or INT variants in a clinical sample with ASD symptoms. Autism Res 2020, 13: 207-220. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: People with autism spectrum disorder (ASD) often have difficulties with higher-order cognitive processes that regulate thoughts and actions during goal-directed behavior, also known as executive function (EF). We studied the association between genetics related to ASD and EF and found a relation between high polygenic score (PGS) for ASD and difficulties with behavior regulation aspects of EF in children and adolescents under assessment for ASD. Furthermore, high PGS for general intelligence was related to social problems.en_US
dc.description.sponsorshipNational Research Council of Norway. Grant Number: Grant #213694 South‐Eastern Norway Regional Health Authority. Grant Number: Grant #39763 Vestre Viken Hospital Trust. Grant Number: Grant #6903002en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.subjectattention deficit/hyperactivity disorder;en_US
dc.subjectautism spectrum disorder;en_US
dc.subjectbehavior rating inventory of executive function;en_US
dc.subjectexecutive function;en_US
dc.subjectpolygenic score;en_US
dc.titleAutism spectrum disorder polygenic scores are associated with every day executive function in children admitted for clinical assessmenten_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.en_US
dc.source.journalAutism Researchen_US
cristin.unitnameSykehuset Innlandet HF

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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