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dc.contributor.authorFarmen, Anette Huuse
dc.contributor.authorGrundt, Jacob Holter
dc.contributor.authorNakling, Ole Jakob
dc.contributor.authorMowinckel, Petter
dc.contributor.authorNakken, Karl Otto
dc.contributor.authorLossius, Morten
dc.coverage.spatialNorwaynb_NO
dc.date.accessioned2020-01-08T14:53:04Z
dc.date.available2020-01-08T14:53:04Z
dc.date.created2019-02-11T09:13:53Z
dc.date.issued2018
dc.identifier.citationEuropean Journal of Neurology. 2018, 1-7.nb_NO
dc.identifier.issn1351-5101
dc.identifier.urihttp://hdl.handle.net/11250/2635413
dc.description.abstractBACKGROUND AND PURPOSE: Studies in women with epilepsy (WWE) regarding pregnancy and labour complications have disclosed contradictory results. Our purpose was to investigate whether WWE have a higher risk of acute caesarean section (CS) or pregnancy complications than women without epilepsy or women with other chronic diseases and, if we found a higher risk, to explore potential explanations. METHODS: The study used prospectively registered obstetric data from the Oppland Perinatal Database in the period 2001-2011, containing information on 18 244 births, including 110 singleton pregnancies in mothers with validated epilepsy. Data regarding epilepsy were collected retrospectively from medical records. RESULTS: Epilepsy was a significant risk factor for acute CS, breech presentation and low birth weight in offspring [odds ratio (OR), 1.93, 95% confidence interval (CI), 1.2-3.1; OR, 2.29, 95% CI, 1.2-4.6 and OR, 2.10, 95% CI, 1.0-4.2, respectively]. In multivariate logistic regression analysis, antiepileptic drug exposure was an independent risk factor for acute CS (OR, 2.00; 95% CI, 1.06-3.77) and polytherapy was a significant risk factor for breech presentation (OR, 5.37; 95% CI, 1.13-25.57). Seizure frequency during pregnancy had no influence on the complication rate. CONCLUSIONS: We found that WWE using antiepileptic drugs during pregnancy had increased rates of acute CS, breech presentation and low birth weight, and that seizure frequency during pregnancy did not influence the complication rate.nb_NO
dc.description.sponsorshipA.H.F. received a research grant from the Department of Research, Innlandet Hospital Trust (project number 150235).nb_NO
dc.language.isoengnb_NO
dc.publisherJohn Wiley & Sons Ltd.nb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.subjectacute caesarean section; epilepsy; pregnancy complicationsnb_NO
dc.titleIncreased rate of acute caesarean sections in women with epilepsy: results from the Oppland Perinatal Database in Norwaynb_NO
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionnb_NO
dc.rights.holder© 2018 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.nb_NO
dc.source.pagenumber617-623nb_NO
dc.source.volume26nb_NO
dc.source.journalEuropean Journal of Neurologynb_NO
dc.source.issue4nb_NO
dc.identifier.doi10.1111/ene.13865
dc.identifier.cristin1675627
cristin.unitcode1991,6,0,0
cristin.unitnameDiv Lillehammer
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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