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dc.contributor.authorKirkhus, Lene
dc.contributor.authorHarneshaug, Magnus
dc.contributor.authorSaltyte Benth, Jurate
dc.contributor.authorGrønberg, Bjørn Henning
dc.contributor.authorRostoft, Siri
dc.contributor.authorBergh, Sverre
dc.contributor.authorHjermstad, Marianne Jensen
dc.contributor.authorSelbæk, Geir
dc.contributor.authorWyller, Torgeir Bruun
dc.contributor.authorKirkevold, Øyvind
dc.contributor.authorBorza, Tom
dc.contributor.authorSaltvedt, Ingvild
dc.contributor.authorJordhøy, Marit Slaaen
dc.identifier.citationJournal of Geriatric Oncology. 2019, 10 (6), 904-912.nb_NO
dc.description.abstractBACKGROUND: Maintaining physical function and quality of life (QoL) are prioritized outcomes among older adults. We aimed to identify potentially modifiable factors affecting older patients' physical function and QoL during cancer treatment. METHODS: Prospective, multicenter study of 307 patients with cancer ≥70 years, referred for systemic treatment. Pre-treatment, a modified geriatric assessment (mGA) was performed, including registration of comorbidities, medications, nutritional status, cognitive function, depressive symptoms (Geriatric Depression Scale-15 [GDS]), and mobility (Timed Up and Go [TUG]). Patient-reported physical function (PF)-, global QoL-, and symptom scores were assessed at baseline, two, four, and six months by the EORTC Quality of Life Core Questionnaire-C30. The impact of mGA components and symptoms on patients' PF and global QoL scores during six months was investigated by linear mixed models. To identify groups following distinct PF trajectories, a growth mixture model was estimated. RESULTS: 288 patients were eligible, mean age was 76.9 years, 68% received palliative treatment. Higher GDS-scores and poorer TUG were independently associated with an overall level of poorer PF and global QoL throughout follow-up, as were more pain, dyspnea, and appetite loss, and sleep disturbance. Three groups with distinct PF trajectories were identified: a poor group exhibiting a non-linear statistically (p < .001) and clinically significant decline (≥10 points), an intermediate group with a statistically (p = .003), but not clinically significant linear decline, and a good group with a stable trajectory. Higher GDS-scores and poorer TUG, more pre-treatment pain and dyspnea were associated with higher odds of belonging to the poor compared to the good PF group. CONCLUSION: Depressive symptoms, reduced mobility, and more physical symptoms increased the risk of decrements in older patients' PF and global QoL scores during cancer treatment, and represent potential targets for interventions aiming at improving these outcomes.nb_NO
dc.description.sponsorshipThis study was funded by Innlandet Hospital Trust and registered at (NCT01742442). We want to thank the cancer clinics at Innlandet Hospital Trust, Oslo University Hospital (OUH) and Akershus University Hospital (AHUS) for their participation in the study. A special thanks to the study nurses at all locations who participated in the inclusion and assessment of patients, and to the local principal investigators at OUH and AHUS:Morten Brændengen and Olav Yri.nb_NO
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.subjectGeriatric assessment; Geriatric oncology; Physical function; Quality of lifenb_NO
dc.titleModifiable factors affecting older patients' quality of life and physical function during cancer treatmentnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.rights.holder© 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://
dc.source.journalJournal of Geriatric Oncologynb_NO
cristin.unitnameAvd Alderspsykiatri
cristin.unitnameDiv Elverum-Hamar

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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
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