Vis enkel innførsel

dc.contributor.authorHjemsæter, Arne Jan
dc.contributor.authorBramness, Jørgen Gustav
dc.contributor.authorDrake, Robert
dc.contributor.authorSkeie, Ivar
dc.contributor.authorMonsbakken, Bent Berntsen
dc.contributor.authorSaltyte Benth, Jurate
dc.contributor.authorLandheim, Anne
dc.coverage.spatialNorwaynb_NO
dc.date.accessioned2019-12-20T13:41:38Z
dc.date.available2019-12-20T13:41:38Z
dc.date.created2019-06-19T13:25:28Z
dc.date.issued2019
dc.identifier.citationHjemsaeter, A. J., et al. (2019). "Mortality, cause of death and risk factors in patients with alcohol use disorder alone or poly-substance use disorders: a 19-year prospective cohort study." BMC Psychiatry 19(1): 101.nb_NO
dc.identifier.issn1471-244X
dc.identifier.urihttp://hdl.handle.net/11250/2634327
dc.description.abstractBackground This study investigated cause of death, mortality rates and explored if baseline characteristics were associated with risk of death in patients with alcohol use disorder alone or poly-substance use disorders. Methods This was a prospective, longitudinal study of patients followed for 19 years after entering specialized treatment for substance use disorders. At baseline 291 patients (mean age 38.3 years, standard deviation 11.4 years, 72% male) with high psychiatric co-morbidity were recruited; 130 (45%) had lifetime alcohol use disorder alone, while 161 (55%) had poly-substance use disorders. Time and causes of death were gathered from the Norwegian Cause of Death Registry. Lifetime psychiatric symptom disorders and substance use disorders at baseline were measured with The Composite International Diagnostic Interview and personality disorders at baseline were measured with The Millon Clinical Multiaxial Inventory II. Results Patients with alcohol use disorder alone more often died from somatic diseases (58% versus 28%, p = 0.004) and more seldom from overdoses (9% versus 33%, p = 0.002) compared with patients with poly-substance use disorders. The crude mortality rate per 100 person year was 2.2 (95% confidence interval: 1.8–2.7), and the standardized mortality rate was 3.8 (95% confidence interval: 3.2–4.6) in the entire cohort during 19 years after entering treatment. Having lifetime affective disorder at baseline was associated with lower risk of death (Hazard Ratio 0.58, 95% confidence interval: 0.37–0.91). Older age was associated to increased risk of death among men (p < 0.001) and non-significantly among patients with poly-substance use (p = 0.057). The difference in association between age and risk of death was significantly different between men and women (p = 0.011) and patients with alcohol use disorder alone and poly-substance use disorders (p = 0.041). Conclusions Patients with alcohol use disorder alone died more often from somatic disease than patients with poly-substance use disorders, and all subgroups of patients had an increased risk of death compared with the general population. Men with long-lasting substance use disorders are a priority group to approach with directed preventive measures for somatic health before they reach 50 years of age.nb_NO
dc.description.sponsorshipThis work was funded by Innlandet Hospital Trust and the Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, with support from the University of Oslo.nb_NO
dc.language.isoengnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectMortality, Risk factors, Substance use disorders, Alcohol, Poly-substance use: psychiatric comorbidity, Cause of death, Longitudinalnb_NO
dc.titleMortality, cause of death and risk factors in patients with alcohol use disorder alone or poly-substance use disorders: A 19-year prospective cohort studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.rights.holder© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.nb_NO
dc.source.pagenumber1-9nb_NO
dc.source.volume19nb_NO
dc.source.journalBMC Psychiatrynb_NO
dc.source.issue101nb_NO
dc.identifier.doi10.1186/s12888-019-2077-8
dc.identifier.cristin1706090
cristin.unitcode1991,0,0,0
cristin.unitcode1991,9,0,0
cristin.unitnameSykehuset Innlandet HF
cristin.unitnameDiv Psykisk helsevern
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal