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dc.contributor.authorAasbrenn, Martin
dc.contributor.authorFarup, Per Grønaas
dc.contributor.authorVidem, Vibeke
dc.coverage.spatialNorwaynb_NO
dc.date.accessioned2019-12-13T12:07:51Z
dc.date.available2019-12-13T12:07:51Z
dc.date.created2019-12-11T14:28:17Z
dc.date.issued2019
dc.identifier.citationScientific Reports. 2019, 9 (1), 17695.nb_NO
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11250/2633199
dc.description.abstractAbstract C-reactive protein, neopterin and lactoferrin are biomarkers of atherosclerotic disease. We aimed to assess changes in these biomarkers after conservative and surgical weight loss interventions in individuals with morbid obesity, to evaluate associations between biomarker changes and changes in body mass index and HbA1c, and to study associations between changes in the biomarkers. C-reactive protein, neopterin and lactoferrin were measured before and after conservative weight loss intervention and bariatric surgery. Data were analysed with mixed models. 137 individuals (mean age 43 years) were included. Body mass index decreased from 42.1 kg/m2 to 38.9 kg/m2 after the conservative intervention, and further to 30.5 kg/m2 after bariatric surgery. All biomarkers decreased after the conservative weight loss intervention. C-reactive protein and lactoferrin continued to decrease following bariatric surgery whereas neopterin remained stable. After adjustments for change in body mass index and HbA1c, all biomarkers decreased significantly after the conservative weight loss intervention, whereas none changed after bariatric surgery. There were no consistent correlations between changes in C-reactive protein, neopterin and lactoferrin. In conclusion, biomarkers of atherosclerosis decreased after weight loss interventions but had different trajectories. Neopterin, a marker related to atherosclerotic plaque stability, decreased after conservative weight loss but not following bariatric surgery.nb_NO
dc.description.sponsorshipThe project was funded by Innlandet Hospital Trust, Brumunddal, Norwaynb_NO
dc.language.isoengnb_NO
dc.publisherSpringer Naturenb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleChanges in C-reactive protein, neopterin and lactoferrin differ after conservative and surgical weight loss in individuals with morbid obesitynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.rights.holder© The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.nb_NO
dc.source.pagenumber1-8nb_NO
dc.source.volume9nb_NO
dc.source.journalScientific Reportsnb_NO
dc.source.issue1nb_NO
dc.identifier.doi10.1038/s41598-019-54107-z
dc.identifier.cristin1759373
cristin.unitcode1991,0,0,0
cristin.unitnameSykehuset Innlandet HF
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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