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dc.contributor.authorHan, Hedong
dc.contributor.authorFang, Xin
dc.contributor.authorWei, Xin
dc.contributor.authorLiu, Yuzhou
dc.contributor.authorJin, Zhicao
dc.contributor.authorChen, Qi
dc.contributor.authorFan, Zhongjie
dc.contributor.authorAaseth, Jan
dc.contributor.authorHiyoshi, Ayako
dc.contributor.authorHe, Jia
dc.contributor.authorCao, Yang
dc.date.accessioned2018-10-10T12:47:41Z
dc.date.available2018-10-10T12:47:41Z
dc.date.created2017-05-23T14:32:11Z
dc.date.issued2017
dc.identifier.citationNutrition Journal. 2017, 16 (26), 1-12.nb_NO
dc.identifier.issn1475-2891
dc.identifier.urihttp://hdl.handle.net/11250/2567462
dc.description.abstractBackground The findings of prospective cohort studies are inconsistent regarding the association between dietary magnesium intake and serum magnesium concentration and the risk of hypertension. We aimed to review the evidence from prospective cohort studies and perform a dose-response meta-analysis to investigate the relationship between dietary magnesium intake and serum magnesium concentrations and the risk of hypertension. Methods We searched systematically PubMed, EMBASE and the Cochrane Library databases from October 1951 through June 2016. Prospective cohort studies reporting effect estimates with 95% confidence intervals (CIs) for hypertension in more than two categories of dietary magnesium intake and/or serum magnesium concentrations were included. Random-effects models were used to combine the estimated effects. Results Nine articles (six on dietary magnesium intake, two on serum magnesium concentration and one on both) of ten cohort studies, including 20,119 cases of hypertension and 180,566 participates, were eligible for inclusion in the meta-analysis. We found an inverse association between dietary magnesium intake and the risk of hypertension [relative risk (RR) = 0.92; 95% CI: 0.86, 0.98] comparing the highest intake group with the lowest. A 100 mg/day increment in magnesium intake was associated with a 5% reduction in the risk of hypertension (RR = 0.95; 95% CI: 0.90, 1.00). The association of serum magnesium concentration with the risk of hypertension was marginally significant (RR = 0.91; 95% CI: 0.80, 1.02). Conclusions Current evidence supports the inverse dose-response relationship between dietary magnesium intake and the risk of hypertension. However, the evidence about the relationship between serum magnesium concentration and hypertension is limitednb_NO
dc.description.sponsorshipThis study was supported by the grant from the Chinese Fourth Round of the Three-year Action Plan on Public Health Discipline and Talent Program: Evidence-based Public Health and Health Economics (No. 15GWZK0901). XF is supported by the Karolinska Institutet doctoral research grant (KID-funds). YC is supported by the Junior Faculty Research Grants (C62412022) of the Institute of Environmental Medicine, Karolinska Institutet, Sweden.nb_NO
dc.language.isoengnb_NO
dc.publisherBMCnb_NO
dc.rightsNavngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/deed.no*
dc.subjectDietary intake;nb_NO
dc.subjectDose-response relationship;nb_NO
dc.subjectHypertension;nb_NO
dc.subjectMagnesium;nb_NO
dc.subjectProspective cohort study;nb_NO
dc.subjectSerum concentration;nb_NO
dc.titleDose-response relationship between dietary magnesium intake, serum magnesium concentration and risk of hypertension: a systematic review and meta-analysis of prospective cohort studiesnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.rights.holder© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.nb_NO
dc.source.pagenumber1-12nb_NO
dc.source.volume16nb_NO
dc.source.journalNutrition Journalnb_NO
dc.source.issue26nb_NO
dc.identifier.doi10.1186/s12937-017-0247-4
dc.identifier.cristin1471637
cristin.unitcode1991,5,0,0
cristin.unitnameDiv Kongsvinger
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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