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dc.contributor.authorStrand, Bjørn Heine
dc.contributor.authorKnapskog, Anne Brita
dc.contributor.authorEdwin, Trine Holt
dc.contributor.authorAmland, Rachel
dc.contributor.authorMjørud, Marit
dc.contributor.authorBjertness, Espen
dc.contributor.authorEngedal, Knut
dc.contributor.authorSelbæk, Geir
dc.coverage.spatialNorwaynb_NO
dc.date.accessioned2018-10-10T07:35:25Z
dc.date.available2018-10-10T07:35:25Z
dc.date.created2018-09-24T12:33:19Z
dc.date.issued2018
dc.identifier.citationPLoS ONE. 2018, 13 (9), .nb_NO
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11250/2567276
dc.descriptionResearch Articlenb_NO
dc.description.abstractAbstract INTRODUCTION: Alzheimer's disease patients are reported to have higher survival rate compared to patients with vascular dementia or dementia with Lewy bodies. There is a paucity of studies investigating survival including persons with cognitive decline and dementia of various aetiologies. OBJECTIVES: We aimed to compare survival for patients with subjective cognitive decline, mild cognitive impairment, Alzheimer's disease, vascular dementia, mixed Alzheimer's/vascular dementia, dementia with Lewy bodies/Parkinson's disease, and other dementias compared to the general Norwegian population, taking into account the role of gender, cognitive function, function in everyday activities, comorbidity and education. METHODS: Patients (N = 4682), ≥65 years, in the The Norwegian register of persons assessed for cognitive symptoms (NorCog) during 2009-2017 were followed for mortality in the National Registry until January 2018. Flexible parametric survival models were applied to estimate relative survival, life expectancy and years of life lost for diagnostic groups compared with the general population. RESULTS: Patients with vascular dementia or dementia with Lewy bodies/Parkinson's had the shortest survival, followed by mixed dementia, Alzheimer's disease, unspecified dementia, mild cognitive impairment and subjective cognitive decline. At age 70 years, men with vascular dementia or dementia with Lewy bodies/Parkinson's had life expectancy of 4.7 years, which corresponded to 10.3 years of life lost compared to the general population. Years of life lost for other diagnoses were 10.0 years for mixed dementia, 9.2 years for Alzheimer's disease, 9.3 years for other dementias, 5.2 years for mild cognitive impairment and 2.2 years for subjective cognitive decline. Corresponding years of life lost in women were: 12.7 years, 10.5 years, 9.8 years, 10.6 years, 7.8 years, and 2.6 years. Poor relative survival among dementia patients was associated with male gender, comorbidity, low cognitive function, and low function in activities of daily living. CONCLUSIONS: Compared with the general population, patients with subjective cognitive decline had no significant loss in life expectancy, while patients with mild cognitive impairment and all dementia subtypes had large losses, especially those with a diagnosis of vascular dementia or dementia with Lewy bodies/Parkinson's.nb_NO
dc.description.sponsorshipThe funder, The Norwegian Association for Public Health, had no role in study design, data collection, data analysis, data interpretation, or writing of the manuscript. BHS had full access to all the data in the study and had final responsibility for the decision to submit for publication.nb_NO
dc.language.isoengnb_NO
dc.relation.urihttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0204436&type=printable
dc.rightsNavngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/deed.no*
dc.titleSurvival and years of life lost in various aetiologies of dementia, mild cognitive impairment (MCI) and subjective cognitive decline (SCD) in Norwaynb_NO
dc.title.alternativeSurvival and years of life lost in various aetiologies of dementia, mild cognitive impairment (MCI) and subjective cognitive decline (SCD) in Norwaynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.rights.holder© 2018 Strand et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.nb_NO
dc.source.pagenumber14nb_NO
dc.source.volume13nb_NO
dc.source.journalPLoS ONEnb_NO
dc.source.issue9nb_NO
dc.identifier.doi10.1371/journal.pone.0204436
dc.identifier.cristin1612924
cristin.unitcode1991,0,0,0
cristin.unitnameSykehuset Innlandet HF
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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