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dc.contributor.authorBerents, Teresa Løvold
dc.contributor.authorCarlsen, Karin C. Lødrup
dc.contributor.authorMowinckel, Petter
dc.contributor.authorSkjerven, Håvard Ove
dc.contributor.authorRolfsjord, Leif Bjarte
dc.contributor.authorNordhagen, Live Solveig
dc.contributor.authorKvenshagen, Bente
dc.contributor.authorHunderi, Jon Olav
dc.contributor.authorBradley, Maria
dc.contributor.authorThorsby, Per Medbøe
dc.contributor.authorCarlsen, Kai-Håkon
dc.contributor.authorGjersvik, Petter
dc.date.accessioned2018-06-01T09:53:29Z
dc.date.available2018-06-01T09:53:29Z
dc.date.created2017-08-31T14:11:10Z
dc.date.issued2017
dc.identifier.citationBMC Pediatrics. 2017, 17:141 1-8.nb_NO
dc.identifier.issn1471-2431
dc.identifier.urihttp://hdl.handle.net/11250/2500027
dc.description.abstractOverweight and atopic dermatitis (AD) are major health problems in most industrialised countries, but the relationship between overweight and AD in infants and young children is unclear. We investigated if weight-for-length at birth, in infancy and at two years, as well as early weight-gain velocity, are associated with the development of AD in early life. Methods Cohort study of infants (n = 642), all living in south-east Norway, hospitalized with acute bronchiolitis (n = 404) or recruited from the general population (n = 238), examined at mean age 5.1 months (enrolment) and at a two-year follow-up visit (n = 499; 78%) at mean age 24.6 months. Exposures were weight-for-length (g/cm) at birth, enrolment and two-year follow-up, and early weight-gain velocity (gram/month from birth to enrolment). Excessive weight-for-length was defined as weight-for-length >95th percentile of WHO child-growth standards. Data on weight-for-length at the three time points were obtained for 435, 428 and 473 children. AD was diagnosed according to the Hanifin & Rajka criteria or from a history of physician-diagnosed AD. We performed multivariate analyses with weight-for-length at birth, at enrolment and at the two-year follow-up visit and with early weight gain velocity for the endpoint AD at each visit. Results In adjusted analyses, excessive weight-for-length at enrolment was associated with concurrent AD (OR 3.03; 95% CI 1.23–7.50) and with AD at two years (OR 2.40; 1.11–5.17). In infants without AD, weight-for-length at enrolment increased the risk of AD at two years, with OR being 1.02 (95% CI 1.00–1.04) per increased gram/cm. AD at two years was not associated with concurrent excessive weight-for-length, nor was AD at any time associated with weight-for-length at birth or with early weight-gain velocity. Conclusions The results suggest that overweight in infancy may contribute to the development of AD in early life, highlighting the need for child health-care professionals to address potential overweight and atopic disease when advising infants’ caregivers.nb_NO
dc.description.sponsorshipInternal funding and from Arne Ingels Foundation, Norwegian Psoriasis and Eczema Association and Norwegian Society of Dermatology and Venereology. The funders had no role in the design and conduct of the study and collection, analysis and interpretation of data nor in writing the manuscript.nb_NO
dc.language.isoengnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectOverweightnb_NO
dc.subjectWeight-for-lengthnb_NO
dc.subjectInfancynb_NO
dc.subjectAtopic dermatitisnb_NO
dc.titleWeight-for-length, early weight-gain velocity and atopic dermatitis in infancy and at two years of age: A cohort studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.rights.holder© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.nb_NO
dc.source.pagenumber1-8nb_NO
dc.source.volume17:141nb_NO
dc.source.journalBMC Pediatricsnb_NO
dc.identifier.doi10.1186/s12887-017-0889-6
dc.identifier.cristin1490203
cristin.unitcode1991,6,3,0
cristin.unitnameAvd Barn
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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