dc.contributor.author | Wortinger, Laura A | |
dc.contributor.author | Øie, Merete Glenne | |
dc.contributor.author | Endestad, Tor | |
dc.contributor.author | Wyller, Vegard Bruun Bratholm | |
dc.date.accessioned | 2018-05-16T13:03:32Z | |
dc.date.available | 2018-05-16T13:03:32Z | |
dc.date.created | 2017-09-07T22:18:52Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/11250/2498447 | |
dc.description.abstract | Abstract Impairments in cognition, pain intolerance, and physical inactivity characterize adolescent chronic fatigue syndrome (CFS), yet little is known about its neurobiology. The right dorsal anterior insular (dAI) connectivity of the salience network provides a motivational context to stimuli. In this study, we examined regional functional connectivity (FC) patterns of the right dAI in adolescent CFS patients and healthy participants. Eighteen adolescent patients with CFS and 18 aged-matched healthy adolescent control participants underwent resting-state functional magnetic resonance imaging. The right dAI region of interest was examined in a seed-to-voxel resting-state FC analysis using SPM and CONN toolbox. Relative to healthy adolescents, CFS patients demonstrated reduced FC of the right dAI to the right posterior parietal cortex (PPC) node of the central executive network. The decreased FC of the right dAI–PPC might indicate impaired cognitive control development in adolescent CFS. Immature FC of the right dAI–PPC in patients also lacked associations with three known functional domains: cognition, pain and physical activity, which were observed in the healthy group. These results suggest a distinct biological signature of adolescent CFS and might represent a fundamental role of the dAI in motivated behavior. | en |
dc.description.sponsorship | Norwegian Research Council, http:// www.forskningsradet.no/en (VBW, grant number 228874); South-Eastern Norway Regional Health Authority, https://www.helse-sorost.no/south- eastern-norway-regional-health-authority (VBW); and the University of Oslo, http://www.uio.no/ english/ (VBW). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | en |
dc.language.iso | eng | |
dc.relation.uri | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184325 | |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.subject | Impairments in cognition | en |
dc.subject | pain intolerance | en |
dc.subject | physical inactivity | en |
dc.subject | adolescent | en |
dc.subject | chronic fatigue syndrome (CFS) | en |
dc.subject | neurobiology | en |
dc.subject | anterior insular (dAI) connectivity | en |
dc.subject | magnetic resonance imaging | en |
dc.subject | loss of associated functions | en |
dc.subject | nervous system dysfunction | en |
dc.subject | alterations in facilitatory | en |
dc.subject | inhibitory pathways | en |
dc.subject | abnormalities of the neuroendocrine system | en |
dc.subject | mental activity intolerance | en |
dc.subject | depression | en |
dc.subject | irritable bowl syndrome | en |
dc.subject | chronic pain | en |
dc.title | Altered right anterior insular connectivity and loss of associated functions in adolescent chronic fatigue syndrome | en |
dc.type | Peer reviewed | en |
dc.type | Journal article | en |
dc.description.version | acceptedVersion | en |
dc.rights.holder | © 2017 Wortinger et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.source.volume | 12 | |
dc.source.journal | PLoS ONE | |
dc.source.issue | 9 | |
dc.identifier.doi | 10.1371/journal.pone.0184325 | |
dc.identifier.cristin | 1491940 | |
cristin.unitcode | 1991,6,0,0 | |
cristin.unitname | Div Lillehammer | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |