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dc.contributor.authorWortinger, Laura A
dc.contributor.authorØie, Merete Glenne
dc.contributor.authorEndestad, Tor
dc.contributor.authorWyller, Vegard Bruun Bratholm
dc.description.abstractAbstract Impairments in cognition, pain intolerance, and physical inactivity characterize adolescent chronic fatigue syndrome (CFS), yet little is known about its neurobiology. The right dorsal anterior insular (dAI) connectivity of the salience network provides a motivational context to stimuli. In this study, we examined regional functional connectivity (FC) patterns of the right dAI in adolescent CFS patients and healthy participants. Eighteen adolescent patients with CFS and 18 aged-matched healthy adolescent control participants underwent resting-state functional magnetic resonance imaging. The right dAI region of interest was examined in a seed-to-voxel resting-state FC analysis using SPM and CONN toolbox. Relative to healthy adolescents, CFS patients demonstrated reduced FC of the right dAI to the right posterior parietal cortex (PPC) node of the central executive network. The decreased FC of the right dAI–PPC might indicate impaired cognitive control development in adolescent CFS. Immature FC of the right dAI–PPC in patients also lacked associations with three known functional domains: cognition, pain and physical activity, which were observed in the healthy group. These results suggest a distinct biological signature of adolescent CFS and might represent a fundamental role of the dAI in motivated behavior.en
dc.description.sponsorshipNorwegian Research Council, http:// (VBW, grant number 228874); South-Eastern Norway Regional Health Authority, eastern-norway-regional-health-authority (VBW); and the University of Oslo, english/ (VBW). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.rightsNavngivelse 4.0 Internasjonal*
dc.subjectImpairments in cognitionen
dc.subjectpain intoleranceen
dc.subjectphysical inactivityen
dc.subjectchronic fatigue syndrome (CFS)en
dc.subjectanterior insular (dAI) connectivityen
dc.subjectmagnetic resonance imagingen
dc.subjectloss of associated functionsen
dc.subjectnervous system dysfunctionen
dc.subjectalterations in facilitatoryen
dc.subjectinhibitory pathwaysen
dc.subjectabnormalities of the neuroendocrine systemen
dc.subjectmental activity intoleranceen
dc.subjectirritable bowl syndromeen
dc.subjectchronic painen
dc.titleAltered right anterior insular connectivity and loss of associated functions in adolescent chronic fatigue syndromeen
dc.typePeer revieweden
dc.typeJournal articleen
dc.rights.holder© 2017 Wortinger et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.source.journalPLoS ONE
cristin.unitnameDiv Lillehammer

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal