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dc.contributor.authorFarup, Per Grønaas
dc.contributor.authorUeland, Thor
dc.contributor.authorRudi, Knut
dc.contributor.authorLydersen, Stian
dc.contributor.authorHestad, Knut
dc.date.accessioned2018-05-04T13:38:28Z
dc.date.available2018-05-04T13:38:28Z
dc.date.created2017-11-05T18:58:18Z
dc.date.issued2017
dc.identifier.citationGastroenterology Research and Practice. 2017, 2017 .nb_NO
dc.identifier.issn1687-6121
dc.identifier.urihttp://hdl.handle.net/11250/2497239
dc.description.abstractBackground. Subjects with depression and unexplained neurological symptoms have a high prevalence of gastrointestinal comorbidity probably related to the brain-gut communication. This study explored associations between functional gastrointestinal disorders (FGID) and inflammatory markers in subjects with these disorders. Methods. The FGID, including irritable bowel syndrome (IBS), were classified according to the Rome III criteria, and degree of symptoms was assessed with IBS symptom severity score (IBS-SSS). A range of interleukins (IL), chemokines and growth factors, tryptophan, and kynurenine were analysed in serum and the cerebrospinal fluid (CSF), and short-chain fatty acids (SCFA) were analysed in the faeces. The results are reported as partial correlation (pc) and values. Results. Sixty-six subjects were included. IBS was associated with high levels of tryptophan () and kynurenine () and low level of IL-10 () in the CSF. IBS-SSS was associated with high tumor necrosis factor and low IL-10 in the CSF; and and and , respectively. Propionic minus butyric acid in faeces was negatively associated with IL-10 in the CSF (, ). Conclusions. FGID were associated with a proinflammatory immune activation in the central nervous system and a disturbed tryptophan metabolism that could have been mediated by the faecal microbiotanb_NO
dc.language.isoengnb_NO
dc.rightsNavngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/deed.no*
dc.subjectGastroenterologynb_NO
dc.subjectcomputer tomographynb_NO
dc.subjectmagnetic resonance imagingnb_NO
dc.subjectdepressionnb_NO
dc.subjectneurological groupnb_NO
dc.subjectfatiguenb_NO
dc.subjectheadachenb_NO
dc.subjectmuscle or other pain syndromesnb_NO
dc.subjectdizzinessnb_NO
dc.subjectataxianb_NO
dc.subjectneurologynb_NO
dc.subjectcentral nervous systemnb_NO
dc.subjectgastrointestinal comorbiditynb_NO
dc.subjectgut-brain interactionnb_NO
dc.subjectbowel disordersnb_NO
dc.subjectimmune activationnb_NO
dc.subjectinflammatorynb_NO
dc.subjecttumor necrosisnb_NO
dc.subjectshort-chain fatty acidsnb_NO
dc.subjectcerebrospinal fluidnb_NO
dc.subjectirritable bowel syndromenb_NO
dc.titleFunctional Bowel Disorders Are Associated with a Central Immune Activationnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.rights.holderCopyright © 2017 Per G. Farup et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.nb_NO
dc.source.pagenumber9nb_NO
dc.source.volume2017nb_NO
dc.source.journalGastroenterology Research and Practicenb_NO
dc.identifier.doi10.1155/2017/1642912
dc.identifier.cristin1511063
cristin.unitcode1991,1,2,0
cristin.unitnameAvd Forskning
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal
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