Anti-rheumatic treatment is not associated with reduction of pentraxin 3 in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis
dc.contributor.author | Deyab, Gia | |
dc.contributor.author | Hokstad, Ingrid | |
dc.contributor.author | Whist, Jon Elling | |
dc.contributor.author | Småstuen, Milada Cvancarova | |
dc.contributor.author | Agewall, Stefan | |
dc.contributor.author | Lyberg, Torstein | |
dc.contributor.author | Bottazzi, Barbara | |
dc.contributor.author | Meroni, Pier Luigi | |
dc.contributor.author | Leone, Roberto | |
dc.contributor.author | Hjeltnes, Gunnbjørg | |
dc.contributor.author | Hollan, Ivana | |
dc.date.accessioned | 2017-06-22T10:56:19Z | |
dc.date.available | 2017-06-22T10:56:19Z | |
dc.date.created | 2017-03-24T21:15:08Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://hdl.handle.net/11250/2446683 | |
dc.description.abstract | Background Pentraxin 3 is proposed to be a marker of inflammation and cardiovascular risk, but its role in inflammatory rheumatic diseases (IRDs) is still uncertain. Therefore, we wanted to examine if anti-rheumatic treatment reduced serum PTX3 (s-PTX3) levels in IRDs, and if s-PTX3 levels were related to other markers of inflammation and to endothelial function (EF). Methods We examined s-PTX3, EF and established inflammatory biomarkers in 114 IRD patients from the PSARA study before and after 6 weeks and 6 months of treatment with methotrexate (MTX) or anti-tumor necrosis factor alpha (anti-TNF) therapy with or without MTX comedication. Results s-PTX3 levels in all IRD diagnoses were above the upper limit of the reference range. In contrast to established inflammatory markers, in particular CRP and ESR, s-PTX3 levels did not change significantly after 6 weeks and 6 months of anti-rheumatic therapy. There was no difference in change in s-PTX3 levels from baseline to 6 weeks and 6 months between MTX monotherapy and anti-TNF regimens. CRP, ESR and EF were not related to changes in s- PTX3 neither in crude nor adjusted analyses. Conclusion IRD patients have increased s-PTX3 levels, which, in contrast to other inflammatory markers, do not seem to improve within 6 months of therapy with MTX and/or anti-TNF. Thus, s- PTX3 might reflect a persisting immune process, even a causal factor of inflammation, not inhibited by the standard anti-rheumatic treatment. Furthermore, even though s-PTX3 is thought to be a strong predictor of cardiovascular prognosis, it was not related to EF. | |
dc.language.iso | eng | |
dc.subject | Revmatiske sykdommer | nb_NO |
dc.title | Anti-rheumatic treatment is not associated with reduction of pentraxin 3 in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis | en |
dc.type | Peer reviewed | en |
dc.type | Journal article | en |
dc.description.version | publishedVersion | |
dc.subject.nsi | VDP::Medisinske Fag: 700 | nb_NO |
dc.source.pagenumber | 14 | nb_NO |
dc.source.journal | PLoS ONE | nb_NO |
dc.identifier.doi | 10.1371/journal.pone.0169830 | |
dc.identifier.cristin | 1461014 | |
cristin.unitcode | 1991,0,0,0 | |
cristin.unitcode | 1991,7,0,0 | |
cristin.unitname | Sykehuset Innlandet HF | |
cristin.unitname | Div Medisinsk service | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 |
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