dc.contributor.author | Chandyo, Ram Krishna | |
dc.contributor.author | Schwinger, Catherine Monika | |
dc.contributor.author | Kvestad, Ingrid | |
dc.contributor.author | Chandyo, Manjeswori Ulak | |
dc.contributor.author | Ranjitkar, Suman | |
dc.contributor.author | Shrestha, Merina | |
dc.contributor.author | Nguyen, Linda Vy | |
dc.contributor.author | Corona-Perez, Diana | |
dc.contributor.author | DeVivo, Immaculata | |
dc.contributor.author | Shrestha, Laxman | |
dc.contributor.author | Strand, Tor Arne | |
dc.date.accessioned | 2024-02-28T11:22:05Z | |
dc.date.available | 2024-02-28T11:22:05Z | |
dc.date.created | 2022-10-16T12:46:00Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Journal of Exposure Science and Environmental Epidemiology. 2022 May;33(3):448-454. doi: 10.1038/s41370-022-00474-1 | en_US |
dc.identifier.issn | 1559-0631 | |
dc.identifier.uri | https://hdl.handle.net/11250/3120299 | |
dc.description.abstract | Background Biomass fuels are still in use for cooking by many households in resource poor countries such as Nepal and is a major source of household air pollution (HAP). Chronic exposure to HAP has been shown to be associated with shorter telomere length in adults. Objectives To measure the association between exposure related to household biomass fuel in infancy and leukocyte telomere length (LTL) at 18–23 months of age among 497 children from Bhaktapur, Nepal. Methods In a prospective cohort study design, we have collected information on household cooking fuel use and several clinical, anthropometric, demographic, and socioeconomic variables. We estimated the association between biomass fuel use and the relative LTL in multiple linear regression models. Results Most of the families (78%) reported liquified petroleum gas (LPG) as the primary cooking fuel, and 18.7% used biomass. The mean relative (SD) LTL was 1.03 (0.19). Children living in households using biomass fuel had on average 0.09 (95% CI: 0.05 to 0.13) units shorter LTL than children in households with no biomass fuel use. The observed association was unaltered after adjusting for relevant confounders. The association between LTL and biomass use was strongest among children from households with ≤2 rooms and without separate kitchen. Significance Exposure to biomass fuel use in early life might have consequences for longevity, and risk of chronic illnesses reflected in shortening of the telomeres. Our findings support the ongoing effort to reduce exposure to biomass fuel in low-resource settings. Impact statements Biomass for cooking is a leading source of household air pollution in low and middle-income countries, contributing to many chronic diseases and premature deaths. Chronic exposure to biomass fuel through oxidative stress and inflammation has been associated with a shortening of the telomeres, a “biological marker” of longevity. This prospective cohort study describes the association between household biomass fuel use and leukocyte telomere length among 497 toddlers. Leukocyte telomere length was significantly shorter among children living in households with biomass fuel than in children from homes where mainly LPG was used for cooking. | en_US |
dc.description.sponsorship | This work was supported by Thrasher Research Fund (award # 11512), the GC Rieber
foundation, the University of Bergen (UiB), and the Innlandet Hospital Trust (grant 150403). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer Nature | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | The association between household biomass fuel use and leukocyte telomere length among toddlers in Bhaktapur, Nepal | en_US |
dc.title.alternative | The association between household biomass fuel use and leukocyte telomere length among toddlers in Bhaktapur, Nepal | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creativecommons.org/licenses/by/4.0/ | en_US |
dc.source.pagenumber | 1-7 | en_US |
dc.source.volume | 33 | en_US |
dc.source.journal | Journal of Exposure Science and Environmental Epidemiology | en_US |
dc.source.issue | 3 | en_US |
dc.identifier.doi | 10.1038/s41370-022-00474-1 | |
dc.identifier.cristin | 2061713 | |
dc.relation.project | Norges forskningsråd: 223269 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |