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dc.contributor.authorAsprusten, Tarjei Tørre
dc.contributor.authorSulheim, Dag
dc.contributor.authorFagermoen, Frode Even
dc.contributor.authorWinger, Anette
dc.contributor.authorSkovlund, Eva
dc.contributor.authorWyller, Vegard Bruun Bratholm
dc.coverage.spatialNorwaynb_NO
dc.date.accessioned2020-01-08T12:42:34Z
dc.date.available2020-01-08T12:42:34Z
dc.date.created2019-02-28T11:19:07Z
dc.date.issued2018
dc.identifier.citationBMJ Paediatrics Open. 2018, 2 . doi: 10.1136/bmjpo-2017-000233nb_NO
dc.identifier.issn2399-9772
dc.identifier.urihttp://hdl.handle.net/11250/2635354
dc.description.abstractObjective: Existing case definitions for chronic fatigue syndrome (CFS) all have disputed validity. The present study investigates differences between adolescent patients with CFS who satisfy the systemic exertion intolerance disease (SEID) diagnostic criteria (SEID-positive) and those who do not satisfy the criteria (SEID-negative). Methods: 120 adolescent patients with CFS with a mean age of 15.4 years (range 12-18 years) included in the NorCAPITAL project (ClinicalTrials ID: NCT01040429) were post-hoc subgrouped according to the SEID criteria based on a comprehensive questionnaire. The two subgroups were compared across baseline characteristics, as well as a wide range of cardiovascular, inflammatory, infectious, neuroendocrine and cognitive variables. Data from 30-week follow-up were used to investigate prognostic differences between SEID-positive and SEID-negative patients. Results: A total of 45 patients with CFS were SEID-positive, 69 were SEID-negative and 6 could not be classified. Despite the fact that clinically depressed patients were excluded in the NorCAPITAL project, the SEID-positive group had significantly higher score on symptoms suggesting a mood disorder (Mood and Feelings Questionnaire): 23.2 vs 13.4, difference 9.19 (95% CI 5.78 to 12.6). No other baseline characteristics showed any group differences. When accounting for multiple comparisons, there were no statistically significant differences between the groups regarding cardiovascular, inflammatory, infectious, neuroendocrine and cognitive variables. Steps per day and Chalder Fatigue Questionnaire at week 30 showed no differences between the groups. Conclusion: The findings question the discriminant and prognostic validity of the SEID diagnostic criteria in adolescent CFS, and suggest that the criteria tend to select patients with depressive symptoms.nb_NO
dc.description.sponsorshipThis study was funded by Health South-East Hospital Trust and the University of Oslo.nb_NO
dc.language.isoengnb_NO
dc.publisherBMJ Publishing Group Ltd.nb_NO
dc.relation.urihttps://bmjpaedsopen.bmj.com/content/bmjpo/2/1/e000233.full.pdf
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.subjectadolescent health; chronic fatigue syndromenb_NO
dc.titleSystemic exertion intolerance disease diagnostic criteria applied on an adolescent chronic fatigue syndrom cohort: evaluation of subgroup differences and prognostic utilitynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.rights.holderThis is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http:// creativecommons. org/ licenses/ by- nc/ 4. 0/ © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.nb_NO
dc.source.pagenumber8nb_NO
dc.source.volume2nb_NO
dc.source.journalBMJ Paediatrics Opennb_NO
dc.source.issue1nb_NO
dc.identifier.doi10.1136/bmjpo-2017-000233
dc.identifier.cristin1681277
cristin.unitcode1991,6,3,0
cristin.unitnameAvd Barn
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse-Ikkekommersiell 4.0 Internasjonal
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