dc.contributor.author | Upadhyay, Ravi Prakash | |
dc.contributor.author | Chandyo, Ram Krishna | |
dc.contributor.author | Kvestad, Ingrid | |
dc.contributor.author | Hysing, Mari | |
dc.contributor.author | Ulak, Manjeswori | |
dc.contributor.author | Ranjitkar, Suman | |
dc.contributor.author | Shrestha, Merina | |
dc.contributor.author | Shrestha, Laxman | |
dc.contributor.author | Strand, Tor A | |
dc.date.accessioned | 2019-12-11T09:10:50Z | |
dc.date.available | 2019-12-11T09:10:50Z | |
dc.date.created | 2019-05-22T19:35:55Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Acta Paediatrica. 2019, 108 (10), 1825-1832. | nb_NO |
dc.identifier.issn | 0803-5253 | |
dc.identifier.uri | http://hdl.handle.net/11250/2632671 | |
dc.description.abstract | Abstract
AIM:
To estimate the extent to which maternal and paternal height modify the association between length-for-age Z-score (LAZ) and neurodevelopmental outcomes assessed by the Bayley Scales of Infant and Toddler Development, 3rd Edition (Bayley-III).
METHODS:
Baseline data from a clinical trial in 600 Nepalese infants aged six to 11 months with LAZ less than -1 were utilised. The primary exposure was the LAZ score, interaction variables were maternal and paternal height, and the outcomes were Bayley-III cognitive, language and motor scaled scores. Linear regression and generalised additive model (GAM) were used to identify potential interactions.
RESULTS:
Linear regression analysis stratified by parental height categories showed that association between unit increase in LAZ and cognitive scaled score differed across maternal (normal height: ß 1.16, 95% CI; 0.75, 1.57 and short height: ß 0.67, 95% CI; 0.28, 1.05) and paternal (normal height: ß 1.32, 95% CI; 0.91, 1.72 and short height: ß 0.61, 95% CI; 0.03, 1.18) height categories. Maternal height also modified the association between LAZ and fine motor scaled score.
CONCLUSION:
The association between LAZ and neurodevelopmental outcomes was attenuated when maternal and paternal height was taken into account. Parental stature should be considered when using LAZ as a proxy for neurodevelopment among infants. | nb_NO |
dc.description.sponsorship | Thrasher Research (award # 11512) fund, GC Rieber funds, and the Research Council of Norway (grant # 234495). | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | John Wiley & Sons Ltd. | nb_NO |
dc.rights | Navngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/deed.no | * |
dc.subject | Infancy; Interaction; Maternal height; Neurodevelopment; Paternal height | nb_NO |
dc.title | Parental height modifies the association between linear growth and neurodevelopment in infancy | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | submittedVersion | nb_NO |
dc.rights.holder | ©2019 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd. | nb_NO |
dc.source.pagenumber | 1825-1832 | nb_NO |
dc.source.volume | 108 | nb_NO |
dc.source.journal | Acta Paediatrica | nb_NO |
dc.source.issue | 10 | nb_NO |
dc.identifier.doi | 10.1111/apa.14820 | |
dc.identifier.cristin | 1699620 | |
cristin.unitcode | 1991,6,0,0 | |
cristin.unitname | Div Lillehammer | |
cristin.ispublished | true | |
cristin.qualitycode | 1 | |