dc.contributor.author | Rolfsjord, Leif Bjarte | |
dc.contributor.author | Bakkeheim, Egil | |
dc.contributor.author | Berents, Teresa Løvold | |
dc.contributor.author | Alm, Johan | |
dc.contributor.author | Skjerven, Håvard Ove | |
dc.contributor.author | Carlsen, Kai-Håkon | |
dc.contributor.author | Mowinckel, Petter | |
dc.contributor.author | Sjöbeck, Ann-Christine | |
dc.contributor.author | Carlsen, Karin C. Lødrup | |
dc.coverage.spatial | Norway | nb_NO |
dc.date.accessioned | 2018-10-10T10:58:22Z | |
dc.date.available | 2018-10-10T10:58:22Z | |
dc.date.created | 2017-10-07T15:22:55Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Journal of Pediatrics. 2017, 184 193-198.e3. | nb_NO |
dc.identifier.issn | 0022-3476 | |
dc.identifier.uri | http://hdl.handle.net/11250/2567379 | |
dc.description.abstract | Abstract
OBJECTIVE:
To identify morning salivary cortisol reference values in infancy and at 2 years of age and to investigate the influence of age, sex and acute bronchiolitis.
STUDY DESIGN:
In this South-East Norwegian cohort study, 308 children hospitalized with moderate to severe acute bronchiolitis in infancy in 2010-2011 were compared with 223 healthy controls included in 2012 by measuring morning salivary cortisol levels at inclusion and at 2 years of age. Samples were collected shortly after awakening after 6 am. The influences of age, sex, and acute bronchiolitis were assessed by regression analysis.
RESULTS:
In infancy, cortisol values were higher in acute bronchiolitis, with an age- and sex-adjusted weighted mean group difference of 13.9 nmol/L (95% CI 8.1-19.7; P < .0001). The median level in reference group was 23.7 nmol/L (95% CI 9.7-119.6). At 2 years of age, sex but not inclusion groups differed, with significantly higher values in girls. The weighted mean of all boys' cortisol levels was 32.4 nmol/L, (95% CI 30.5-34.3), and all girls' levels were 36.9 nmol/L (95% CI 34.7-39.2; P < .003).
CONCLUSIONS:
Salivary cortisol levels were higher at 2 years of age than in infancy in the reference group, were higher in girls than in boys at 2 years of age, and were higher in infants at the time of acute bronchiolitis than in healthy infants.
TRIAL REGISTRATION:
ClinicalTrials.gov: NCT00817466. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Elsevier | nb_NO |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.subject | adrenocortical function; | nb_NO |
dc.subject | allergic disease; | nb_NO |
dc.subject | allergic rhinitis; | nb_NO |
dc.subject | asthma; | nb_NO |
dc.subject | health-related quality of life; | nb_NO |
dc.subject | infants; | nb_NO |
dc.subject | morning salivary cortisol; | nb_NO |
dc.subject | stress; | nb_NO |
dc.subject | toddlers; | nb_NO |
dc.title | Morning salivary cortisol in young children: reference values and the effects of age, sex, and acute bronchiolitis | nb_NO |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.description.version | publishedVersion | nb_NO |
dc.rights.holder | © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). http://dx.doi.org10.1016/j.jpeds.2017.01.064 THE JOURNAL OF PEDIATRICS • www.jpeds.com ORIGINAL ARTICLES 193 | nb_NO |
dc.source.pagenumber | 193-198 | nb_NO |
dc.source.volume | 184 | nb_NO |
dc.source.journal | Journal of Pediatrics | nb_NO |
dc.identifier.doi | 10.1016/j.jpeds.2017.01.064 | |
dc.identifier.cristin | 1502993 | |
dc.relation.project | Regionale forskningsfond Innlandet: 150189 | nb_NO |
cristin.unitcode | 1991,2,0,0 | |
cristin.unitname | Div Elverum-Hamar | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |